Thesis-1982-Kelly.pdf (3.3 MB)
Biochemical studies of opiate action
thesis
posted on 2018-01-19, 13:08 authored by Peter D. KellyThe opium poppy has for centuries been associated with the
deadening of pain and production of euphoria. The pharmacologically
active agent was identified as morphine, the major alkaloid component
of opium. Single doses of morphine relieve all but the most severe pain.
Unfortunately, morphine does cause other effects such as constipation,
hypotension and respiratory depression. The most serious disadvantage,
however, is the onset of tolerance and physical dependence after prolonged administration. This leads to the social problem of addiction.
Particularly important in this respect is the abused narcotic, heroin. [Continues.]
Funding
Reckitt and Colman Ltd.
History
School
- Science
Department
- Chemistry
Publisher
© Peter David KellyPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 2.5 Generic (CC BY-NC-ND 2.5) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/2.5/Publication date
1982Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en