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Thesis-1982-Kelly.pdf (3.3 MB)

Biochemical studies of opiate action

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thesis
posted on 2018-01-19, 13:08 authored by Peter D. Kelly
The opium poppy has for centuries been associated with the deadening of pain and production of euphoria. The pharmacologically active agent was identified as morphine, the major alkaloid component of opium. Single doses of morphine relieve all but the most severe pain. Unfortunately, morphine does cause other effects such as constipation, hypotension and respiratory depression. The most serious disadvantage, however, is the onset of tolerance and physical dependence after prolonged administration. This leads to the social problem of addiction. Particularly important in this respect is the abused narcotic, heroin. [Continues.]

Funding

Reckitt and Colman Ltd.

History

School

  • Science

Department

  • Chemistry

Publisher

© Peter David Kelly

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 2.5 Generic (CC BY-NC-ND 2.5) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/2.5/

Publication date

1982

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

  • en

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