Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/28285

Title: Dehydration of amides to nitriles under conditions of a catalytic appel reaction
Authors: Shipilovskikh, Sergei A.
Vaganov, Vladimir Yu
Denisova, Elena I.
Rubtsov, Aleksandr E.
Malkov, Andrei V.
Issue Date: 2018
Publisher: © American Chemical Society (ACS)
Citation: SHIPILOVSKIKH, S.A. ...et al., 2018. Dehydration of amides to nitriles under conditions of a catalytic appel reaction. United States, Organic Letters, 20 (3), pp.728–731.
Abstract: A highly expedient protocol for a catalytic Appel-type dehydration of amides to nitriles has been developed that employs oxalyl chloride and triethylamine along with triphenylphosphine oxide as a catalyst. The reactions are usually complete in less than 10 min with only a 1 mol % catalyst loading. The reaction scope includes aromatic, heteroaromatic, and aliphatic amides, including derivatives of α-hydroxy and α-amino acids.
Description: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/10.1021/acs.orglett.7b03862.
Sponsor: The authors thank Russian Science Foundation for grant 15-13-00092.
Version: Accepted for publication
DOI: 10.1021/acs.orglett.7b03862
URI: https://dspace.lboro.ac.uk/2134/28285
Publisher Link: https://doi.org/10.1021/acs.orglett.7b03862
Appears in Collections:Published Articles (Chemistry)

Files associated with this item:

File Description SizeFormat
Malkov_2017 nitriles SASH-02d-bw.pdfAccepted version158.48 kBAdobe PDFView/Open


SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.