SHIPILOVSKIKH, S.A. ...et al., 2018. Dehydration of amides to nitriles under conditions of a catalytic appel reaction. United States, Organic Letters, 20 (3), pp.728–731.
A highly expedient protocol for a catalytic Appel-type dehydration of amides to nitriles has been developed that employs oxalyl chloride and triethylamine along with triphenylphosphine oxide as a catalyst. The reactions are usually complete in less than 10 min with only a 1 mol % catalyst loading. The reaction scope includes aromatic, heteroaromatic, and aliphatic amides, including derivatives of α-hydroxy and α-amino acids.
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The authors thank Russian Science Foundation for grant 15-13-00092.