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Title: Dehydration of amides to nitriles under conditions of a catalytic appel reaction
Authors: Shipilovskikh, Sergei A.
Vaganov, Vladimir Yu
Denisova, Elena I.
Rubtsov, Aleksandr E.
Malkov, Andrei V.
Issue Date: 2018
Publisher: © American Chemical Society (ACS)
Citation: SHIPILOVSKIKH, S.A. ...et al., 2018. Dehydration of amides to nitriles under conditions of a catalytic appel reaction. United States, Organic Letters, 20 (3), pp.728–731.
Abstract: A highly expedient protocol for a catalytic Appel-type dehydration of amides to nitriles has been developed that employs oxalyl chloride and triethylamine along with triphenylphosphine oxide as a catalyst. The reactions are usually complete in less than 10 min with only a 1 mol % catalyst loading. The reaction scope includes aromatic, heteroaromatic, and aliphatic amides, including derivatives of α-hydroxy and α-amino acids.
Description: This paper is in closed access until 10th Jan 2019.
Sponsor: The authors thank Russian Science Foundation for grant 15-13-00092.
Version: Accepted for publication
DOI: 10.1021/acs.orglett.7b03862
URI: https://dspace.lboro.ac.uk/2134/28285
Publisher Link: https://doi.org/10.1021/acs.orglett.7b03862
Appears in Collections:Closed Access (Chemistry)

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