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Title: Preventing crystal agglomeration of pharmaceutical crystals using temperature cycling and a novel membrane crystallization procedure for seed crystals generation
Authors: Simone, Elena
Othman, Rahimah
Vladisavljevic, Goran T.
Nagy, Zoltan K.
Keywords: Agglomeration
Membrane crystallization
Temperature cycling
Seeded crystallization
Issue Date: 2018
Publisher: © the Authors. Published by MDPI AG
Citation: SIMONE, E. ...et al., 2018. Preventing crystal agglomeration of pharmaceutical crystals using temperature cycling and a novel membrane crystallization procedure for seed crystals generation. Pharmaceutics, 10: 17.
Abstract: In this work, a novel membrane crystallization system was used to crystallize micro-sized seeds of piroxicam monohydrate by reverse antisolvent addition. Membrane crystallization seeds were compared with seeds produced by conventional antisolvent addition and polymorphic transformation of a fine powdered sample of piroxicam form I in water. The membrane crystallization process allowed for a consistent production of pure monohydrate crystals with narrow size distribution and without significant agglomeration. The seeds were grown in 350 g of 20:80 w/w acetone-water mixture. Different seeding loads were tested and temperature cycling was applied in order to avoid agglomeration of the growing crystals during the process. Focused beam reflectance measurement (FBRM); and particle vision and measurement (PVM) were used to monitor crystal growth; nucleation and agglomeration during the seeded experiments. Furthermore; Raman spectroscopy was used to monitor solute concentration and estimate the overall yield of the process. Membrane crystallization was proved to be the most convenient and consistent method to produce seeds of highly agglomerating compounds; which can be grown via cooling crystallization and temperature cycling.
Description: This is an Open Access Article. It is published by MDPI under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: Financial support was provided by the European Research Council grant no. [280106-CrySys]. R. Othman gratefully acknowledges the financial support given for this work through the Ministry of Higher Education Malaysia.
Version: Published
DOI: 10.3390/pharmaceutics10010017
URI: https://dspace.lboro.ac.uk/2134/28334
Publisher Link: https://doi.org/10.3390/pharmaceutics10010017
ISSN: 1999-4923
Appears in Collections:Published Articles (Chemical Engineering)

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