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Title: A comparative study of coupled preferential crystallizers for the efficient resolution of conglomerate-forming enantiomers
Authors: Majumder, Aniruddha
Nagy, Zoltan K.
Keywords: Chiral resolution
Coupled crystallizer
Crystallization modelling
Issue Date: 2017
Publisher: MDPI © The Authors
Citation: MAJUMDER, A. and NAGY, Z.K., 2017. A comparative study of coupled preferential crystallizers for the efficient resolution of conglomerate-forming enantiomers. Pharmaceutics, 9 (4), 55.
Abstract: The separation of enantiomers is of great importance due to their possible differences in therapeutic properties. Preferential crystallization in various configurations of coupled batch crystallizers is used as an attractive means to separate the conglomerate-forming enantiomers from racemic mixtures. However, the productivity of such batch processes can be limited by the nucleation of the counter enantiomer and consumption of the supersaturation. In this work, a recently proposed process configuration, which uses coupled mixed suspension mixed product removal (MSMPR) with liquid phase exchange, is investigated by simulation studies. A detailed study on the effect of process parameters (e.g., feed flow rate, seed mass, and liquid phase exchange) on the productivity and yield of the coupled MSMPR has been presented. Moreover, a comparison of various coupled crystallizer configurations is carried out. It is shown through simulation studies that the productivity of the enantiomeric separation can be significantly improved compared to the previously proposed batch modes when the continuous configuration is used. The effect of nucleation kinetic parameters on the performances of various crystallizer configurations is studied as well. A set of coupled population balance equations (PBEs) was used to describe the evolution of the crystal phase of the both enantiomers in each vessel. These equations were solved numerically using the quadrature method of moments. The insights obtained in this study will be useful in the process design of coupled crystallizer systems.
Description: This is an Open Access Article. It is published by MDPI under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: Funding is acknowledged from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007–2013)/ERC grant agreement No. (280106-CrySys)
Version: Published
DOI: 10.3390/pharmaceutics9040055
URI: https://dspace.lboro.ac.uk/2134/28415
Publisher Link: https://doi.org/10.3390/pharmaceutics9040055
Appears in Collections:Published Articles (Chemical Engineering)

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