A simple "one-pot" method has been developed for the amino-methylation
of ketones possessing an α-hydrogen under aprotic conditions. The procedure
utilises chlorotrimethylsilane in the sequential formation of the intermediate
trimethylsilyl enol ether and methylene iminium species. The methylene
iminium ion intermediate is generated either from a dialkylaminoalkoxymethane
or a bis-(dialkylamino)methane. [Continues.]
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.