Thesis-1991-Fairhurst.pdf (6.22 MB)
Stereochemical aspects in the aminoalkylation reactions of ketones
thesis
posted on 2018-02-08, 12:52 authored by Robin A. FairhurstA simple "one-pot" method has been developed for the amino-methylation
of ketones possessing an α-hydrogen under aprotic conditions. The procedure
utilises chlorotrimethylsilane in the sequential formation of the intermediate
trimethylsilyl enol ether and methylene iminium species. The methylene
iminium ion intermediate is generated either from a dialkylaminoalkoxymethane
or a bis-(dialkylamino)methane. [Continues.]
Funding
SERC.
History
School
- Science
Department
- Chemistry
Publisher
© Robin A. FairhurstPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 2.5 Generic (CC BY-NC-ND 2.5) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/2.5/Publication date
1991Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en