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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/31884

Title: Cellular senescence: immunosurveillance and future immunotherapy
Authors: Burton, Dominick G.A.
Stolzing, Alexandra
Keywords: Ageing
Issue Date: 2018
Publisher: © Elsevier
Citation: BURTON, D.G.A. and STOLZING, A., 2018. Cellular senescence: immunosurveillance and future immunotherapy. England, Ageing Research Reviews, 43, pp. 17-25.
Abstract: In response to persistent DNA damage, induction into cell senescence promotes an immunogenic program which facilitates immune clearance of these damaged cells. Under physiological conditions, senescent cells can activate both innate and adaptive immune responses, functioning to maintain tissue homeostasis. In addition, emerging findings suggest that programmed induction of cell senescence may be important for regulating reproductive processes, partly facilitated by immune clearance. However, likely owing to ageing of the immune system, a failure to eliminate senescent cells can contribute to their persistence in tissues, leading to the development and progression of age-related diseases. Such immune failure may in part be due to activation of the senescence program in immune cells, leading to their dysfunction. Furthermore, senescent cells under certain biological contexts have been shown to instead promote immune suppression, a response that may reflect differences between an acute verses chronic senescent phenotype. In this review, we provide an overview of the research to date concerning senescence immunosurviellance, including a focused discussion on the mechanisms by which macrophages may recognise senescent cells. Senescence immunotherapy strategies as an alternative to senolytics for the removal of senescent cells will also be discussed.
Description: This paper was accepted for publication in the journal Ageing Research Reviews and the definitive published version is available at https://doi.org/10.1016/j.arr.2018.02.001
Version: Accepted for publication
DOI: 10.1016/j.arr.2018.02.001
URI: https://dspace.lboro.ac.uk/2134/31884
Publisher Link: https://doi.org/10.1016/j.arr.2018.02.001
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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