The thesis reports a study of new methods of modification of the
medicinally important quinazoline system by the use of Reissert compounds.
Previous attempts to employ this approach have utilized two phase conditions
leading only to ring opened products. We have discovered that reaction of
4-phenylquinazoline with an acid chloride and trimethylsilyl cyanide as
source of cyanide ion in a single phase system selectively gives a high
yield route to the corresponding 1-acyl-2-cyano-1,2-dihydroquinazoline. [Continues.]
A master's thesis submitted in partial fulfilment of the requirements for the award of Master of Philosophy at Loughborough University.