It is known that morphine-6-glucuronide is more potent than morphine, but it is
difficult and expensive to produce. Our aim was to synthesise an analogue(s) of
morphine-6-glucuronide which would have similar or enhanced properties, but that
could be obtained via a simple synthetic route. It is hoped that such a compound could
be used to treat terminally ill cancer patients. Due to the enhanced potency a smaller
dose of the drug would be required to effect the same analgesic effect as morphine, and
this may help to reduce the effect of morphine tolerance. [Continues.]
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.