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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/32407

Title: The synthesis of morphine-6-glucuronide analogues as potential analgesics
Authors: Di Pretoro, Anna M.A.
Issue Date: 1996
Publisher: © Anna M.A. Di Pretoro
Abstract: It is known that morphine-6-glucuronide is more potent than morphine, but it is difficult and expensive to produce. Our aim was to synthesise an analogue(s) of morphine-6-glucuronide which would have similar or enhanced properties, but that could be obtained via a simple synthetic route. It is hoped that such a compound could be used to treat terminally ill cancer patients. Due to the enhanced potency a smaller dose of the drug would be required to effect the same analgesic effect as morphine, and this may help to reduce the effect of morphine tolerance. [Continues.]
Description: A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.
Sponsor: British Technology Group Ltd.
URI: https://dspace.lboro.ac.uk/2134/32407
Appears in Collections:PhD Theses (Chemistry)

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