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Title: Regional homogeneity, resting-state functional connectivity and amplitude of low frequency fluctuation associated with creativity measured by divergent thinking in a sex-specific manner
Authors: Takeuchi, Hikaru
Taki, Yasuyuki
Nouchi, Rui
Yokoyama, Ryoichi
Kotozaki, Yuka
Nakagawa, Seishu
Sekiguchi, Atsushi
Iizuka, Kunio
Yamamoto, Yuki
Hanawa, Sugiko
Araki, Tsuyoshi
Makoto Miyauchi, Carlos M.
Shinada, Takamitsu
Sakaki, Kohei
Nozawa, Takayuki
Ikeda, Shigeyuki
Yokota, Susumu
Magistro, Daniele
Sassa, Yuko
Kawashima, Ryuta
Keywords: Resting state
Regional coherence
Divergent thinking
Anterior temporal lobe
Sex difference
Functional connectivity
Issue Date: 2017
Publisher: © Elsevier
Citation: TAKEUCHI, H. ...et al., 2017. Regional homogeneity, resting-state functional connectivity and amplitude of low frequency fluctuation associated with creativity measured by divergent thinking in a sex-specific manner. NeuroImage, 152, pp. 258-269.
Abstract: Brain connectivity is traditionally thought to be important for creativity. Here we investigated the associations of creativity measured by divergent thinking (CMDT) with resting-state functional magnetic imaging (fMRI) measures and their sex differences. We examined these relationships in the brains of 1277 healthy young adults. Whole-brain analyses revealed a significant interaction between verbal CMDT and sex on (a) regional homogeneity within an area from the left anterior temporal lobe (b) on the resting state functional connectivity (RSFC) between the mPFC and the left inferior frontal gyrus and (c) on fractional amplitude of low frequency fluctuations (fALFF) in several distinct areas, including the precuneus and middle cingulate gyrus, left middle temporal gyrus, right middle frontal gyrus, and cerebellum. These interactions were mediated by positive correlations in females and negative correlations in males. These findings suggest that greater CMDT in females is reflected by (a) regional coherence (regional homogeneity) of brain areas responsible for representing and combining concepts as well as (b) the efficient functional connection (RSFC) between the key areas for the default state of cognitive activity and speech production, and (c) greater spontaneous neural activity (fALFF) during the resting of brain areas involved in frontal lobe functions, default cognitive activities, and language functions. Furthermore, these findings suggest that the associations between creativity and resting state brain connectivity patterns are different between males and females.
Description: This paper was accepted for publication in the journal NeuroImage and the definitive published version is available at https://doi.org/10.1016/j.neuroimage.2017.02.079
Sponsor: This study was supported by JST/RISTEX, JST/CREST, a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306), and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012) from the Ministry of Education, Culture, Sports, Science, and Technology.
Version: Accepted for publication
DOI: 10.1016/j.neuroimage.2017.02.079
URI: https://dspace.lboro.ac.uk/2134/32543
Publisher Link: https://doi.org/10.1016/j.neuroimage.2017.02.079
ISSN: 1053-8119
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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