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Title: Human, animal and environmental contributors to antibiotic resistance in low resource settings: integrating behavioural, epidemiological and One Health approaches
Authors: Rousham, Emily K.
Unicomb, Leanne
Islam, Mohammad Aminul
Keywords: Low and middle income countries
One-health
Antibiotics
Issue Date: 2018
Publisher: © The Authors. Published by The Royal Society.
Citation: ROUSHAM, E.K., UNICOMB, L. and ISLAM, M.A., 2018. Human, animal and environmental contributors to antibiotic resistance in low resource settings: integrating behavioural, epidemiological and One Health approaches. Proceedings of the Royal Society B: Biological Sciences, 285: 20180332.
Abstract: Antibiotic resistance (ABR) is recognised as a One Health challenge because of the rapid emergence and dissemination of resistant bacteria and genes among humans, animals and the environment on a global scale. However, there is a paucity of research assessing ABR contemporaneously in humans, animals and the environment in low resource settings. This critical review seeks to identify the extent of One Health research on antibiotic resistance in low and middle income countries (LMICs). Existing research has highlighted hotspots for environmental contamination; food-animal production systems that are likely to harbour reservoirs or promote transmission of ABR as well as high and increasing human rates of colonisation with ABR commensal bacteria such as Escherichia coli. However, very few studies have integrated all three components of the One Health spectrum to understand the dynamics of transmission of AMR and the prevalence of community-acquired resistance in humans and animals. Microbiological, epidemiological and social science research is needed at community and population levels across the One Health spectrum in order to fill the large gaps in knowledge of ABR in low resource settings.
Description: This paper was accepted for publication in the journal Proceedings of the Royal Society B: Biological Sciences and the definitive published version is available at http://doi.org/10.1098/rspb.2018.0332
Sponsor: The authors gratefully acknowledge funding support from the UK Antimicrobial Resistance Cross Council Initiative (NERC/BBSRC/MRC) grant no. NE/N019555/1 with additional support from the EPSRC Bridging the Gaps in AMR award EP/M027341/1.
Version: Accepted for publication
DOI: 10.1098/rspb.2018.0332
URI: https://dspace.lboro.ac.uk/2134/32555
Publisher Link: http://doi.org/10.1098/rspb.2018.0332
ISSN: 1471-2954
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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