Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/32970

Title: Optimized vascular network by stereolithography for tissue engineered skin
Authors: Han, Xiaoxiao
Courseaus, Julien
Khamassi, Jamel
Nottrodt, Nadine
Engelhardt, Sascha
Jacobsen, Frank
Bierwisch, Claas
Meyer, Wolfdietrich
Walter, Torsten
Weisser, Jurgen
Jaeger, Raimund
Bibb, Richard J.
Harris, Russell A.
Keywords: Artificial vascular network
Skin tissue engineering
Additive manufacturing
Stereolithography
Design optimisation
Issue Date: 2018
Publisher: © The Authors. Published by WHIOCE
Citation: HAN, X. ...et al., 2018. Optimized vascular network by stereolithography for tissue engineered skin. International Journal of Bioprinting, 4(2): 134.
Abstract: This paper demonstrates the essential and efficient methods to design, and fabricate optimal vascular network for tissue engineering structures based on their physiological conditions. Comprehensive physiological requirements in both micro and macro scales were considered in developing the optimisation design for complex vascular vessels. The optimised design was then manufactured by stereolithography process using materials that are biocompatible, elastic and surface bio-coatable. The materials are self-developed photocurable resin consist of BPA-ethoxylated-diacrylate, lauryl acrylate and isobornylacrylate with Irgacure® 184, the photoinitiator. The optimised vascular vessel offers many advantages: 1) it provides the maximum nutrient supply; 2) it minimises the recirculation areas and 3) it allows the wall shear stress on the vessel in a healthy range. The stereolithography manufactured vascular vessels were then embedded in the hydrogel seeded with cells. The results of in vitro studies show that the optimised vascular network has the lowest cell death rate compared with a pure hydrogel scaffold and a hydrogel scaffold embedded within a single tube in day seven. Consequently, these design and manufacture routes were shown to be viable for exploring and developing a high range complex and specialised artificial vascular networks.
Description: This is an Open Access Article. It is published by WHIOCE under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC). Full details of this licence are available at: http://creativecommons.org/licenses/by-nc/4.0/
Sponsor: This work is part of the project ArtiVasc 3D (http://www.artivasc.eu/). It is financially supported by the European Union’s Seventh Framework Programme (FP/2007-2013) under grant agreement No. 263416 (ArtiVasc 3D).
Version: Published
DOI: 10.18063/ijb.v4i2.134
URI: https://dspace.lboro.ac.uk/2134/32970
Publisher Link: https://doi.org/10.18063/ijb.v4i2.134
ISSN: 2424-8002
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

Files associated with this item:

File Description SizeFormat
Han_134-743-3-PB.pdfPublished version2.34 MBAdobe PDFView/Open

 

SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.