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Expert opinion on three phage therapy related topics: bacterial phage resistance, phage training and prophages in bacterial production strains
journal contribution
posted on 2018-05-18, 10:08 authored by Christine Rohde, Gregory Resch, Jean-Paul Pirnay, Bob G. Blasdel, Laurent Debarbieux, Daniel Gelman, Andrzej Gorski, Ronen Hazan, Isabelle Huys, Elene Kakabadze, Malgorzata Lobocka, Alice Maestri, Gabriel Magno de Freitas Almeida, Khatuna Makalatia, Danish MalikDanish Malik, Ivana Maslanova, Maia Merabishvili, Roman Pantucek, Thomas Rose, Dana Stverakova, Hilde Van Raemdonck, Gilbert Verbeken, Nina ChanishviliPhage therapy is increasingly put forward as a “new” potential tool in the fight against antibiotic resistant infections. During the “Centennial Celebration of Bacteriophage Research” conference in Tbilisi, Georgia on 26–29 June 2017, an international group of phage researchers committed to elaborate an expert opinion on three contentious phage therapy related issues that are hampering clinical progress in the field of phage therapy. This paper explores and discusses bacterial phage resistance, phage training and the presence of prophages in bacterial production strains while reviewing relevant research findings and experiences. Our purpose is to inform phage therapy stakeholders such as policy makers, officials of the competent authorities for medicines, phage researchers and phage producers, and members of the pharmaceutical industry. This brief also points out potential avenues for future phage therapy research and development as it specifically addresses those overarching questions that currently call for attention whenever phages go into purification processes for application.
Funding
This work was supported through the PHAGEFORWARD project of the fourth European Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) call: “AMR Networks/Working Groups”.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
VirusesVolume
10Issue
4Citation
ROHDE, C. ... et al., 2018. Expert opinion on three phage therapy related topics: bacterial phage resistance, phage training and prophages in bacterial production strains. Viruses, 10 (4), 178; https://doi.org/10.3390/v10040178.Publisher
© by the authors. Licensee MDPI, Basel, SwitzerlandVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/Acceptance date
2018-04-03Publication date
2018Notes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).eISSN
1999-4915Publisher version
Language
- en