Thesis-1990-Burford.pdf (39.05 MB)
Chemotaxonomic study of feverfew
thesis
posted on 2018-05-21, 16:11 authored by Mark D. BurfordA chemotaxonomic identification of the herbal remedy Chrysanthemum
parthenium (feverfew) and its reported adulterants Chrysanthemum vulgaris
(tansy) and Chamomile vulgaris (German chamomile) has been undertaken. An
initial survey investigated the distribution of phenolic compounds in the
plants using a RP-HPLC diode-array system. A chemometric analysis of the
data distinguished feverfew from its adulterant German chamomile, though
tansy was ambiguous.
In the light of these findings, the GLC of essential oils and in
particular the reported active ingredient parthenolide, were used as
alternative fingerprinting markers. Conventional extraction techniques were
investigated but were considered unsuitable. Supercritical fluid extraction
(SFE) was extensively examined and successfully yielded the claimed active
ingredient. The determination of the essential oil content of the plants
enabled feverfew to be unambiguously identified from both adulterants. The
technique was sufficiently sensitive to assign authenticity to feverfew
products. During this study a detailed investigation was made of the SFE
conditions required to give complete extraction and recovery of the terpenes
from a model matrix and from the plant material.
Funding
SERC.
History
School
- Science
Department
- Chemistry
Publisher
© M.D. BurfordPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
1990Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en