Cathodic stripping voltammetry of peptide complexes

Small peptides containing the histidine residue are considered as models of the metal binding site of bioactive peptides and proteins. The present study has been concerned with the cathodic stripping voltammetry of the copper complexes of imidazole (the parent molecule), and several histidine containing peptides; glycylglycyl-L-histidine (GGH), glycyl-L-histidylglycine (GHG), L-histidylglycine (HG), glycyl-L-histidine (GH), Carnosine (Car) and thyrotropine releasing factor(TRF). Accumulation and reduction mechanisms were further studied by cyclic voltammetry, and indirect cathodic stripping voltammetric method of determining these peptides has been developed. [Continues.]