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Title: Regulation of metabolic disease-associated inflammation by nutrient sensors
Authors: Yamashita, Alex S.
Belchior, Thiago
Lira, Fabio S.
Bishop, Nicolette
Wessner, Barbara
Rosa, Jose C.
Festuccia, William T.
Keywords: Glucose
Amino acids
Fatty acids
Nutrient sensors
Obesity and insulin resistance
Issue Date: 2018
Publisher: Hindawi Publishing Corporation © The Authors
Citation: YAMASHITA, A.S. ... et al, 2018. Regulation of metabolic disease-associated inflammation by nutrient sensors. Mediators of Inflammation, 2018: 8261432.
Abstract: Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β-cell dysfunction as important hallmarks. Recent evidence indicates that the chronic, low-grade inflammation commonly associated with visceral obesity plays a major role connecting the excessive visceral fat deposition with the development of insulin resistance and pancreatic β31 cell dysfunction. Herein we review the mechanisms by which nutrients modulate obesity associated inflammation.
Description: This is an Open Access Article. It is published by the Hindawi Publishing Corporation under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/. This is the accepted version of the article. It will be replaced by the published version once this is available.
Sponsor: Funding was provided by Sao Paulo Research Foundation (FAPESP) to ASY (#13/15825-5), TB (#15/22983-1) and to WTF (#10/52191-6 and 15/19530-5).
Version: Published version
DOI: 10.1155/2018/8261432
URI: https://dspace.lboro.ac.uk/2134/33681
Publisher Link: https://doi.org/10.1155/2018/8261432
ISSN: 0962-9351
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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