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Title: Synthetic biology strategies for improving microbial synthesis of "green" biopolymers
Authors: Anderson, Lisa A.
Islam, M. Ahsanul
Prather, Kristala L.
Keywords: Metabolic engineering
Synthetic biology
Polysaccharide
Biomaterials
Secretion
Issue Date: 2018
Publisher: © The American Society for Biochemistry and Molecular Biology, Inc.
Citation: ANDERSON, L.A., ISLAM, M.A. and PRATHER, K.L., 2018. Synthetic biology strategies for improving microbial synthesis of "green" biopolymers. Journal of Biological Chemistry, 293 (14), pp.5053-5061.
Abstract: Polysaccharide-based biopolymers have many material properties relevant to industrial and medical uses, including as drug delivery agents, wound-healing adhesives, and food additives and stabilizers. Traditionally, polysaccharides are obtained from natural sources. Microbial synthesis offers an attractive alternative for sustainable production of tailored biopolymers. Here, we review synthetic biology strategies for select “green” biopolymers: cellulose, alginate, chitin, chitosan, and hyaluronan. Microbial production pathways, opportunities for pathway yield improvements, and advances in microbial engineering of biopolymers in various hosts are discussed. Taken together, microbial engineering has expanded the repertoire of green biological chemistry by increasing the diversity of biobased materials.
Description: This research was originally published in the Journal of Biological Chemistry. Lisa A. Anderson, M. Ahsanul Islam, and Kristala L. J. Prather. Synthetic biology strategies for improving microbial synthesis of "green" biopolymers. J. Biol. Chem. 2018; 293:pp5053-pp5061. © the American Society for Biochemistry and Molecular Biology.
Sponsor: This work was supported by the National Institute of General Medical Sciences (NIGMS, Grant P50 GM098792) and the National Science Foundation (NSF, Grant MCB-1517913).
Version: Accepted for publication
DOI: 10.1074/jbc.TM117.000368
URI: https://dspace.lboro.ac.uk/2134/33693
Publisher Link: https://doi.org/10.1074/jbc.TM117.000368
ISSN: 0021-9258
Appears in Collections:Published Articles (Chemical Engineering)

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