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Title: High magnesium corrosion rate has an effect on osteoclast and mesenchymal stem cell role during bone remodelling
Authors: Maradze, Diana
Musson, David
Zheng, Yufeng
Cornish, Jillian
Lewis, Mark P.
Liu, Yang
Keywords: Biomaterials – cells
Fracture repair
Mesenchymal stem cells
Musculoskeletal models
Issue Date: 2018
Publisher: Springer Nature © The Author(s)
Citation: MARADZE, D. ... et al, 2018. High magnesium corrosion rate has an effect on osteoclast and mesenchymal stem cell role during bone remodelling. Scientific Reports, 8 (1), 10003.
Abstract: The aim of this study was to gain an understanding on the collective cellular effects of magnesium (Mg) corrosion products on the behaviour of cells responsible for bone formation and remodelling. The response of mesenchymal stem cells (MSCs) and osteoclast cells to both soluble (Mg ions) and insoluble (granule) corrosion products were recapitulated in vitro by controlling the concentration of the corrosion products. Clearance of corrosion granules by MSCs was also inspected by TEM analysis at sub-cellular level. The effect of Mg corrosion products varied depending on the state of differentiation of cells, concentration and length of exposure. The presence of the corrosion products significantly altered the cells' metabolic and proliferative activities, which further affected cell fusion/differentiation. While cells tolerated higher than physiological range of Mg concentration (16 mM), concentrations below 10 mM were beneficial for cell growth. Furthermore, MSCs were shown to contribute to the clearance of intercellular corrosion granules, whilst high concentrations of corrosion products negatively impacted on osteoclast progenitor cell number and mature osteoclast cell function.
Description: This is an Open Access Article. It is published by Springer Nature under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: DM’s PhD studentship was supported by The EPSRC (EP/F500491/1) Centre of Doctor Training in Regenerative Medicine and the exchange activity with University of Auckland was funded by SkelGen under Marie Sklodowska-Curie Research and Innovation Staff Exchange programme (FP7-PEOPLE-2012-IRSES, 318553).
Version: Published
DOI: 10.1038/s41598-018-28476-w
URI: https://dspace.lboro.ac.uk/2134/34081
Publisher Link: https://doi.org/10.1038/s41598-018-28476-w
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)
Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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