Thesis-1971-Massey.pdf (3.85 MB)
Studies on the biosynthesis of the morphine alkaloids
thesis
posted on 2018-07-26, 09:02 authored by Stewart R. MasseyEarlier work on the biosynthesis of morphine in the opium
poppy, Papaver somniferum, is reviewed in chapter I.
A variety of unnatural codeine precursors, closely related
structurally to codeine and labelled with 3H at C-2, have been
prepared and administered to P. somniferum plants. Their in vivo
3-0-demethylation to give the corresponding morphine compounds
was investigated using radiodilution techniques. Each of the
feeding experiments utilised [N-methyl-14C]codeine as an
internal standard and the efficiency of the unnatural 3-0-demethylations
was compared with that observed for the natural
conversion of codeine into morphine. Dihydrodesoxycodeine was
more efficiently converted into dihydrodesoxymorphine than was
codeine into morphine. The least efficiently demethylated
unnatural precursor of the series was 1-bromocodeine. [Continues.]
Funding
Science Research Council.
History
School
- Science
Department
- Chemistry
Publisher
© Stewart R. MasseyPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
1971Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en