Thesis-2010-Begum.pdf (7.29 MB)
Mathematical modelling of dermatological disease and recovery
thesis
posted on 2018-08-06, 10:58 authored by Najida BegumThe National Health Service in the UK spends over £1bn every year treating dermatological
conditions such as chronic wounds. These wounds exhibit poor vascularisation prone to
polymicrobial infections where slow- or non-healing are typical, and spend prolonged periods in
the inflammatory stage. Chronic wounds such as leg and foot ulcers develop in patients with
illnesses such as diabetes, where circulation is compromised and regular treatment and monitoring
are essential. Many management strategies and new therapies have been introduced
to combat chronic wounds and include growth factor therapy and skin substitutes. Although
one of the greatest concerns is preventing an acute wound becoming chronic, and retrieving
the normal healing before amputations are needed. Other dermatological conditions such as
psoriasis affects 2–3% of the UK's population and shares some common traits with the wound
healing phenomena, however mathematical models in this area are scarce.
The thesis proposes a number of new mathematical models, to describe dermatological skin
growth and recovery in both the epidermal and dermal membranes. [Continues.]
History
School
- Science
Department
- Mathematical Sciences
Publisher
© Najida BegumPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2010Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en