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Title: | Chitin in a dual role as substrate for Streptomyces griseus and as adsorbent for streptomycin produced during fermentation |
Authors: | Meanwell, Richard J.L. Shama, Gilbert |
Keywords: | Chitin Streptomyces Streptomycin Stirred bioreactors Vertical basket bioreactors |
Issue Date: | 2006 |
Publisher: | © Elsevier |
Citation: | MEANWELL, R.J.L. and SHAMA, G., 2006. Chitin in a dual role as substrate for Streptomyces griseus and as adsorbent for streptomycin produced during fermentation. Enzyme and microbial technology, 38(5), pp. 657-664 |
Abstract: | Streptomycin production from chitin by Streptomyces griseus was compared using
two different types of bioreactor. The first was equipped with a combined U-shaped
paddle and Rushton impeller. Also employed was a bioreactor of novel design in
which the chitin was contained in a wire mesh basket that was totally submerged in a
liquid salts medium. During operation the chitin was gently fluidised by air admitted
into the basket. Fermentation was continued in both bioreactors until maximum
antibiotic titres were achieved whereupon operation was interrupted to allow the
streptomycin adsorbed to the chitin substrate to be extracted into pH 3.0 buffer before
continuing fermentation of the same batch of chitin a second time. At a chitin
concentration of 10 % (w/v) the highest streptomycin yields (c. 5.5 mg/L) were
obtained using the stirred bioreactor, however growth occurred more rapidly in the
vertical basket bioreactor. |
Description: | This is a journal article. It was published in the journal, Enzyme and microbial technology [© Elsevier] and the definitive version is available at: doi:10.1016/j.enzmictec.2005.07.017 |
URI: | https://dspace.lboro.ac.uk/2134/3482 |
ISSN: | 0141-0229 |
Appears in Collections: | Published Articles (Chemical Engineering)
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