Thesis-1979-Burton.pdf (4.34 MB)
The synthesis of potential analgesics derived from thebaine
thesis
posted on 2018-09-12, 11:49 authored by Michael BurtonThe thesis describes the synthesis of novel bridged thebaine derivatives with heterocyclic rings attached to C-7 and a study of the associated chemistry. Use has been made of the α-hydrazide (3) formed from the α-ester (2), itself prepared by Diels-Alder addition of methyl acrylate to thebaine (1). From this hydrazide, either directly or via other novel open-chain precursors, three new heterocyclic ring systems attached to the 6,14-endoetheno-6,7,8,14-tetrahydrothebaine moiety (T) have been obtained. These are the α- and β-1,2,4-triazines (4 and 5), the 1,2,4-triazol-5-thione (6) and the 1,3,4-oxadiazole (7). [Continues.]
Funding
Science Research Council.
History
School
- Science
Department
- Chemistry
Publisher
© Michael BurtonPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
1979Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en