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Title: Design criteria and applications of multi-channel parallel microfluidic module
Authors: Huang, Yichao
Han, Tengteng
Xuan, Jin
Xu, Hong
Wang, Yongle
Zhang, Li
Keywords: Microfluidic
Scale-up design criteria
Modular design
Flow resistance module
Issue Date: 2018
Publisher: © IOP Publishing
Citation: HUANG, Y. ... et al, 2018. Design criteria and applications of multi-channel parallel microfluidic module. Journal of Micromechanics and Microengineering, 28 (10), 105021.
Abstract: The microfluidic technology for function microsphere synthesis has high control precision. However, the throughput is too low for industrial scale-up applications. Current scale-up design focuses on a multi-channel in 2D, in which the distribution uniformity parameter δ increases linearly, resulting in the deterioration of the flow distribution performance. The 3D modular scale-up strategy could greatly alleviate this problem, but no design principles have been developed yet. For the first time, this paper establishes the microfluidic 3D scale-up design criteria. Based on the modular design concept, the design method of 2D and 3D throughput scale-up parameters N and M, distribution uniformity parameters δ and β, and microchannel design parameter KRwere proposed. The equivalent resistance coefficient was defined, and the influence of different parameters on a 2D array and 3D stack was analyzed. Furthermore, the error correction method was studied. It was found that the two-stage scale-up process contradicted each other. A good scale-up performance of one stage led to the limitation of another stage. Increasing the resistance of each channel Rucould both increase the two-stage scale-up performance, which was an important factor. A single-module scale-up system with 8 channels in a single array and 10 arrays in a vertical stack, which had 80 channels in total, was designed and fabricated based on the proposed design criteria for generating Chitosan/TiO2composite microspheres. The average particle size was 539.65 μm and CV value was about 3.59%. The throughput was 480 ml h-1, which effectively increased the throughput scale and the product quality.
Description: This paper is closed access until 17th August 2019.
Sponsor: The research was supported by the research grant (No. 16DZ2260600) from Science and Technology Commission of Shanghai Municipality, and the Fundamental Research Funds for the Central Universities (222201717012, 222201718005).
Version: Accepted for publication
DOI: 10.1088/1361-6439/aad746
URI: https://dspace.lboro.ac.uk/2134/35048
Publisher Link: https://doi.org/10.1088/1361-6439/aad746
ISSN: 0960-1317
Appears in Collections:Closed Access (Chemical Engineering)

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