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|Title: ||A substitution-dependent light-up fluorescence probe for selectively detecting Fe3+ ions and its cell imaging application|
|Authors: ||Feng, Xing|
Kwok, Ryan T.
Elsegood, Mark R.J.
Lam, Jacky W.Y.
Tang, Ben Zhong
|Keywords: ||Acid dissociation constant|
|Issue Date: ||2018|
|Publisher: ||© Wiley|
|Citation: ||FENG, X. ... et al, 2018. A substitution-dependent light-up fluorescence probe for selectively detecting Fe3+ ions and its cell imaging application. Advanced Functional Materials, 28 (35), 1802833.|
|Abstract: ||Deliberate design of specific and sensitive molecular probes with distinctive physical/chemical properties for analyte sensing is of great significance. Herein, by taking advantage of the position-dependent substituent effects, an aggregation-induced emission featured iron (III) probe from ortho-substituted pyridinyl-functionalized tetraphenylethylene (TPE-o-Py) is synthesized. It displays high sensitivity and selectivity toward iron (III) detection. The recognition arises from the position isomer of ortho-substitution, and the fact that TPE-o-Py has a low acid dissociation constant (pKa) that is close to that of hydrolyzed Fe3+. Importantly, TPE-o-Py as a light-up fluorescence probe could be employed for Fe3+sensing in living cells with a pronounced red-shift in fluorescence emission.|
|Description: ||This paper is closed access until 8th July 2019.|
|Sponsor: ||This work was supported by the National Science Foundation of China (21602014, 21788102, and 51620105009), the Research Grants Council of Hong Kong (16308016, C6009-17G, C2014-15G, and A-HKUST605/16), the Innovation and Technology Commission (ITC-CNERC14SC01 and ITS/254/17), the Science and Technology Plan of Shenzhen (JCYJ20160229205601482, JCY20170818113602462, and JCYJ20160428150429072), and International Science & Technology Cooperation Program of Guangzhou (201704030069).|
|Version: ||Accepted for publication|
|Publisher Link: ||https://doi.org/10.1002/adfm.201802833|
|Appears in Collections:||Closed Access (Chemistry)|
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