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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/35176

Title: A substitution-dependent light-up fluorescence probe for selectively detecting Fe3+ ions and its cell imaging application
Authors: Feng, Xing
Li, Ying
He, Xuewen
Liu, Haixiang
Zhao, Zheng
Kwok, Ryan T.
Elsegood, Mark R.J.
Lam, Jacky W.Y.
Tang, Ben Zhong
Keywords: Acid dissociation constant
Aggregation‐induced emission
Cell imaging
Iron (III)
Molecular recognition
Issue Date: 2018
Publisher: © Wiley
Citation: FENG, X. ... et al, 2018. A substitution-dependent light-up fluorescence probe for selectively detecting Fe3+ ions and its cell imaging application. Advanced Functional Materials, 28 (35), 1802833.
Abstract: Deliberate design of specific and sensitive molecular probes with distinctive physical/chemical properties for analyte sensing is of great significance. Herein, by taking advantage of the position-dependent substituent effects, an aggregation-induced emission featured iron (III) probe from ortho-substituted pyridinyl-functionalized tetraphenylethylene (TPE-o-Py) is synthesized. It displays high sensitivity and selectivity toward iron (III) detection. The recognition arises from the position isomer of ortho-substitution, and the fact that TPE-o-Py has a low acid dissociation constant (pKa) that is close to that of hydrolyzed Fe3+. Importantly, TPE-o-Py as a light-up fluorescence probe could be employed for Fe3+sensing in living cells with a pronounced red-shift in fluorescence emission.
Description: This paper is closed access until 8th July 2019.
Sponsor: This work was supported by the National Science Foundation of China (21602014, 21788102, and 51620105009), the Research Grants Council of Hong Kong (16308016, C6009-17G, C2014-15G, and A-HKUST605/16), the Innovation and Technology Commission (ITC-CNERC14SC01 and ITS/254/17), the Science and Technology Plan of Shenzhen (JCYJ20160229205601482, JCY20170818113602462, and JCYJ20160428150429072), and International Science & Technology Cooperation Program of Guangzhou (201704030069).
Version: Accepted for publication
DOI: 10.1002/adfm.201802833
URI: https://dspace.lboro.ac.uk/2134/35176
Publisher Link: https://doi.org/10.1002/adfm.201802833
ISSN: 1616-301X
Appears in Collections:Closed Access (Chemistry)

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