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Title: Association of body mass index, and waist to hip ratio with brain structure
Authors: Hamer, Mark
Batty, G. David
Keywords: Obesity
Body mass index
Abdominal adiposity
Issue Date: 2018
Publisher: © American Academy of Neurology
Citation: HAMER, M. and BATTY, G.D., 2018. Association of body mass index, and waist to hip ratio with brain structure. Neurology, 92 (6), e594-600.
Abstract: Objective: We examined the association of body mass index (BMI) and waist to hip ratio (WHR) with brain volume. Methods: We used cross-sectional data from UK Biobank study (n=9,652 ; aged 55.4±7.5 yrs; 47.9% men). Measures included BMI, WHR, and total fat mass as ascertained from bioimpedance. Brain images were produced using structural magnetic resonance imaging. Results: After adjustment for a range of covariates, higher levels of all obesity measures were related to lower grey matter volume: BMI per SD (beta coefficient=-4113; 95% confidence interval: -4862, -3364), WHR (-4272; -5280, -3264), fat mass (-4590; -5386, -3793). The combination of overall obesity (BMI≥30 kg/m2 ) and central obesity (WHR>0.85 women; >0.90 men) was associated with the lowest grey matter compared with lean adults. In hypothesis-free testing with a Bonferroni correction, obesity was also related to various regional brain volumes including Caudate, Putamen, Pallidum, and Nucelus Accumbens. No associations between obesity and white matter were apparent. Conclusion: The combination of heightened BMI and WHR may be an important risk factor for grey matter atrophy.
Description: This paper is closed access.
Sponsor: This research has been conducted using the UK Biobank Resource under Application Number 23476. MH acknowledges support from the NIHR Leicester Biomedical Research Centre. GDB is supported by the UK Medical Research Council (MR/P023444/1) and the US National Institute on Aging (1R56AG052519-01; 1R01AG052519-01A1).
Version: Accepted for publication
DOI: 10.1212/WNL.0000000000006879
URI: https://dspace.lboro.ac.uk/2134/35303
Publisher Link: https://doi.org/10.1212/WNL.0000000000006879
ISSN: 0028-3878
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

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