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Gender-specific risk factors for incident sarcopenia: 8 years follow up of the English Longitudinal Study of Aging

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posted on 2018-10-23, 12:56 authored by Lin Yang, Lee Smith, Mark Hamer
Background: The aetiology of age-related sarcopenia is not known. Objectives: To investigate if risk of developing sarcopenia differs by gender; and to identify gender-specific risk factors of incident sarcopenia, in a large population-based cohort of older English adults. Methods: The sample (n=3,404; age 63.4 (SD 7.7) yrs; 54.1% female) comprised older community dwelling adults recruited from the English Longitudinal Study of Ageing. Sarcopenia was defined as hand grip <26kg in men, <16kg in women. Handgrip strength was assessed at baseline (2004/5) and repeated at follow up (2012/13). Analysed risk factors included baseline anthropometric measures, smoking, vigorous and moderate physical activity, depressive symptoms, chronic illnesses, and wealth. After excluding participants with sarcopenia at baseline, multivariate logistic regressions were used to explore baseline risk factors for incident sarcopenia. Results: During 8 years follow up, 208 and 287 cases of sarcopenia were identified in men (n=1564) and women (n=1840), respectively. Women were at 20% (age adjusted OR=1.20, 95% CI, 0.98, 1.47) higher risk of developing sarcopenia than men. The inverse association between physical activity and sarcopenia risk was observed at moderate (OR=0.44, 95% CI, 0.27, 0.67) and vigorous (0.53, 95% CI, 0.31, 0.82) intensities in men and only vigorous (OR=0.44, 95% CI, 0.28, 0.68) intensity in women. Social factors, such as wealth, and chronic health conditions appeared to be more strongly associated with sarcopenia in men. Conclusion: Women are at higher risk of developing incident sarcopenia than men and this is likely explained by a range of gender-specific risk factors.

History

School

  • Sport, Exercise and Health Sciences

Published in

Journal of Epidemiology and Community Health

Citation

YANG, L., SMITH, L. and HAMER, M., 2018. Gender-specific risk factors for incident sarcopenia: 8 years follow up of the English Longitudinal Study of Aging. Journal of Epidemiology and Community Health, 73(1), pp. 86–88.

Publisher

BMJ Publishing Group © The Authors

Version

  • AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

2018-10-17

Publication date

2018

Notes

This paper was accepted for publication in the journal Journal of Epidemiology and Community Health and the definitive published version is available at http://dx.doi.org/10.1136/jech-2018-211258

ISSN

0143-005X

eISSN

1470-2738

Language

  • en

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