acs.cgd.8b00853.pdf (1.66 MB)
The role of residence time distribution in the continuous steady-state mixed suspension mixed product removal crystallization of glycine
journal contribution
posted on 2018-11-19, 11:54 authored by Iyke Onyemelukwe, Anna R. Parsons, Helen P. Wheatcroft, Amy Robertson, Zoltan NagyZoltan Nagy, Chris RiellyChris RiellyIn this work, a vacuum-driven intermittent transfer technique has been implemented to solve transfer line blockage issues and facilitate steady-state cooling crystallization studies of α-glycine in a single- and 2-stage MSMPR crystallizer. Experimental residence time distribution (RTD) analysis of the stirred-tank MSMPR cascade is performed using an imperfect pulse method of the axial dispersion model to benchmark the mixing performance against that of tubular crystallizers, and determine the influence of RTD on steady-state size distribution of α-glycine product. Process analytical technology (PAT) is used to monitor and understand crystallization process dynamics, and the effect of MSMPR operating temperature, mean residence time, and number of MSMPR stages on mean particle size, crystal size distribution, and yield is studied. Results show the significance of nucleation-growth mechanisms alongside RTD in determining steady-state size distribution; and the need for optimum control of supersaturation to reap the benefit of improved RTDs provided by multistage MSMPR crystallizers.
Funding
This work was supported by the EPSRC (EP/I033459/1) Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallization (CMAC) and the Doctoral Training Centre in Continuous Manufacturing and Crystallization (EP/K503289/1).
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
Crystal Growth & DesignVolume
19Issue
1Pages
66 - 80Citation
ONYEMELUKWE, I. ... et al, 2018. The role of residence time distribution in the continuous steady-state mixed suspension mixed product removal crystallization of glycine. Crystal Growth & Design, 19 (1), pp.66-80.Publisher
© American Chemical SocietyVersion
- AM (Accepted Manuscript)
Publisher statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.cgd.8b00853.Acceptance date
2018-11-15Publication date
2018-11-15ISSN
1528-7483eISSN
1528-7505Publisher version
Language
- en