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Title: Metabolic effects of breaking prolonged sitting with standing or light walking in older South Asians and White Europeans: a randomized acute study.
Authors: Yates, Thomas E.
Edwardson, Charlotte L.
Celis-Morales, Carlos
Biddle, Stuart J.H.
Bodicoat, Danielle H.
Davies, Melanie J.
Esliger, Dale W.
Henson, Joseph
Kazi, A.
Khunti, Kamlesh
Sattar, Naveed
Sinclair, Alan J.
Rowlands, Alex V.
Velayudhan, Latha
Zaccardi, Francesco
Gill, Jason M.R.
Keywords: Ethnicity
Physical activity
Sedentary behaviour
Walking
Issue Date: 2018
Publisher: © the Authors. Published by OUP
Citation: YATES, T.E. ... et al., 2018. Metabolic effects of breaking prolonged sitting with standing or light walking in older South Asians and White Europeans: a randomized acute study. The Journals of Gerontology: Series A, Doi: 10.1093/gerona/gly252
Abstract: Background: Prolonged sitting is common in older adults and associated with insulin resistance and poor cardiometabolic health. We investigate whether breaking prolonged sitting with regular short bouts of standing or light walking improves postprandial metabolism in older white European and South Asian adults and whether effects are modified by ethnic group. Methods: Thirty South Asian (15 women) and 30 white European (14 women) older adults (65-79 years) undertook three experimental conditions in random order. 1) Prolonged sitting: continuous sitting during a 7.5 h observation period consuming two standardised mixed meals. 2) Standing breaks: sitting interrupted with 5 mins of standing every 30 mins (accumulating 60 mins of standing over the observation period). 3) Walking Breaks: sitting interrupted with 5 mins of self-paced light walking every 30 mins (accumulating 60 mins of walking). Blood samples (glucose, insulin, triglycerides) and blood pressure were sampled regularly throughout each condition. Results: Compared with prolonged sitting, walking breaks lowered postprandial insulin by 16.3 mU/l, (95% CI 19.7, 22.0) with greater reductions (p = 0.029) seen in South Asians (22.4 mU/l; 12.4, 32.4) than White Europeans (10.3 mU/l; 5.9, 14.7). Glucose (0.3 mmol/l; 0.1, 0.5) and blood pressure (4 mmHg; 2, 6), but not triglycerides, were lower with walking breaks, with no ethnic differences. Standing breaks did not improve any outcome. Conclusions: Breaking prolonged sitting with short bouts of light walking, but not standing, resulted in clinically meaningful improvements in markers of metabolic health in older adults, with South Asians gaining a greater reduction in postprandial insulin.
Description: This is an Open Access Article. It is published by OUP under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: The research was supported by: the UK Research Councils’ Lifelong Health and Wellbeing Initiative in partnership with the Department of Health [grant number MR/K025090/1]; the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre; and the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care – East Midlands (NIHR CLAHRC – EM); and the Leicester Clinical Trials Unit
Version: Accepted for publication
DOI: 10.1093/gerona/gly252
URI: https://dspace.lboro.ac.uk/2134/36215
Publisher Link: https://doi.org/10.1093/gerona/gly252
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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