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Title: Paraoxonase 1 gene polymorphisms (Q192R and L55M) are associated with coronary artery disease susceptibility in Asian Indians
Authors: Kaur, Sumanpreet
Bhatti, Gurjit Kaur
Vijayvergiya, Rajesh
Singh, Puneetpal
Mastana, Sarabjit S.
Tewari, Rupinder
Bhatti, Jasvinder Singh
Keywords: Paraoxonase 1
Gene variants
Coronary artery disease
Asian Indians
Issue Date: 2018
Publisher: © the Authors. Published by Karger Publishers
Citation: KAUR, S. ... et al., 2018. Paraoxonase 1 gene polymorphisms (Q192R and L55M) are associated with coronary artery disease susceptibility in Asian Indians. International Journal of Diabetes and Metabolism, 21, pp. 38-47.
Abstract: Background: Coronary artery disease (CAD) is a complex metabolic disorder in which lifestyle and genetic factors are known to play key roles in pathogenesis. The paraoxonase 1 (PON1) enzyme has a defensive effect against CAD progression, as it safeguards low-density lipoproteins (LDLs) from oxidative modifications. The most extensively studied genetic variants in the PON1 gene are Q192R and L55M, which have been related with LDL antioxidative activity and risk of CAD. Objective: The present case-control study intended to examine the Q192R and L55M polymorphisms and their association with the risk of CAD patients in north Indians. Methods: A total of 872 subjects (412 CAD patients and 460 controls) were recruited from north India. The PON1 gene was amplified and genotypes were studies using PCR-RFLP. χ2 analysis was performed to compare genotype/allele frequencies in patients and controls. Results: The present study indicated abdominal obesity, elevated body mass index, and dyslipidemia with increased levels of total cholesterol and triglycerides as well as reduced high-density lipoprotein cholesterol in CAD subjects compared to healthy controls (p < 0.05). Logistic regression analysis of the data revealed an association of the RR genotype of the Q192R polymorphism with an about 2-fold elevated risk of CAD (OR = 2.23, 95% CI = 1.47–3.37, p = 0.0001). Contrariwise, the L55M polymorphism did not show significant association with CAD (OR = 1.81, 95% CI = 0.66–4.95, p = 0.326). Conclusions: The Q192R polymorphism in the PON1 gene may be a susceptibility gene associated with increased risk of CAD in an Asian Indian population.
Description: This is an Open Access Article. It is published by Karger under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor: This study was financially supported by University Grants Commission (UGC), New Delhi under a Maulana Azad National Fellowship awarded to S. Kaur.
Version: Published
DOI: 10.1159/000494508
URI: https://dspace.lboro.ac.uk/2134/36284
Publisher Link: https://doi.org/10.1159/000494508
ISSN: 1606-7754
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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