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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/36345

Title: Photocatalytic production of bisabolene from green microalgae mutant: process analysis and kinetic modeling
Authors: Harun, Irina
del Rio-Chanona, Ehecatl Antonio
Wagner, Jonathan L.
Lauersen, Kyle J.
Zhang, Dongda
Hellgardt, Klaus
Keywords: Photocatalysis
Kinetic modelling
Excreted biofuels
Process optimisation
Issue Date: 2018
Publisher: © American Chemical Society
Citation: HARUN, I. ... et al, 2018. Photocatalytic production of bisabolene from green microalgae mutant: process analysis and kinetic modeling. Industrial & Engineering Chemistry Research, 57 (31), pp.10336–10344.
Abstract: Currently, algal fuel research has commenced to shift toward genetically engineered mutants able to express and excrete desired products directly into the culture. In this study, a mutant strain of Chlamydomonas reinhardtii, engineered for bisabolene (alternative biodiesel) excretion, was cultivated at different illumination and temperatures to investigate their effects on cell growth and bisabolene production. Moreover, a kinetic model was constructed to identify the desirable conditions for biofuel synthesis. Three original contributions were concluded. First, this work confirmed that bisabolene was partially synthesized independently of biomass growth, indicating its feasibility for continuous production. Second, it was found that while bisabolene synthesis was independent of light intensity, it was strongly affected by temperature, resulting in conflicting desirable conditions for cell growth and product synthesis. Finally, through model prediction, optimal operating conditions were identified for mutant growth and bisabolene synthesis. This study therefore paves the way toward chemostat production and process scale-up.
Description: This paper is closed access until 5 July 2019.
Sponsor: This project received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement 640720. This project also received funding from the EPSRC project (EP/P016650/1, P65332). I.H. acknowledges funding from the Ministry of Higher Education, Malaysia and University Putra Malaysia.
Version: Accepted for publication
DOI: 10.1021/acs.iecr.8b02509
URI: https://dspace.lboro.ac.uk/2134/36345
Publisher Link: https://doi.org/10.1021/acs.iecr.8b02509
ISSN: 0888-5885
Appears in Collections:Closed Access (Chemical Engineering)

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