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Title: Recommendations for clinical translation of nanoparticle-enhanced radiotherapy
Authors: Ricketts, Kate
Ahmad, Reem
Beaton, Laura
Cousins, Brian G.
Critchley, Kevin
Davies, Mark
Evans, Stephen
Fenuyi, Ifeyemi
Gavriilidis, Asterios
Harmer, Quentin J.
Jayne, David
Jefford, Monica
Loizidou, Marilena
Macrobert, Alexander
Moorcroft, Sam
Naasani, Imad
Ong, Zhan Yuin
Prise, Kevin M.
Rannard, Steve
Richards, Thomas
Schettino, Giuseppe
Sharma, Ricky A.
Tillement, Olivier
Wakefield, Gareth
Williams, Norman R
Yaghini, Elnaz
Royle, Gary
Issue Date: 2018
Publisher: © the Authors. Published by the British Institute of Radiology
Citation: RICKETTS, K. ... et al., 2018. Recommendations for clinical translation of nanoparticle-enhanced radiotherapy. The British Journal of Radiology, 91:20180325.
Abstract: A multi-disciplinary cooperative for nanoparticle-enhanced radiotherapy (NERT) has been formed to review the current status of the field and identify key stages towards translation. Supported by the Colorectal Cancer Healthcare Technologies Cooperative, the cooperative comprises a diverse cohort of key contributors along the translation pathway including academics of physics, cancer and radio-biology, chemistry, nanotechnology and clinical trials, clinicians, manufacturers, industry, standards laboratories, policy makers and patients. Our aim was to leverage our combined expertise to devise solutions towards a roadmap for translation and commercialisation of NERT, in order to focus research in the direction of clinical implementation, and streamline the critical pathway from basic science to the clinic. A recent meeting of the group identified barriers to and strategies for accelerated clinical translation. This commentary reports the cooperative's recommendations. Particular emphasis was given to more standardised and cohesive research methods, models and outputs, and reprioritised research drivers including patient quality of life following treatment. Nanoparticle design criteria were outlined to incorporate scalability of manufacture, understanding and optimisation of biological mechanisms of enhancement and in vivo fate of nanoparticles, as well as existing design criteria for physical and chemical enhancement. In addition, the group aims to establish a long-term and widespread international community to disseminate key findings and create a much-needed cohesive body of evidence necessary for commercial and clinical translation.
Description: This is in closed access until 17th September 2019.
Sponsor: We acknowledge Colorectal Cancer Healthcare Technology Cooperative funding to the team at UCL to host the NERT multidisciplinary cooperative workshop
Version: Published
DOI: 10.1259/bjr.20180325
URI: https://dspace.lboro.ac.uk/2134/36353
Publisher Link: https://doi.org/10.1259/bjr.20180325
Appears in Collections:Closed Access (Chemistry)

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