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|Title: ||A shortcut approach for decision-making and operational analysis of an integrated end-to-end continuous pharmaceutical process|
|Authors: ||Mansouri, Seyed Soheil|
Udugama, Isuru A.
Huusom, Jakob K.
Gernaey, Krist V.
Layer of protection analysis (LOPA)
|Issue Date: ||2018|
|Publisher: ||© Elsevier|
|Citation: ||MANSOURI, S.S. ... et al, 2018. A shortcut approach for decision-making and operational analysis of an integrated end-to-end continuous pharmaceutical process. IN: Eden, M.R., Ierapetritou, M.G. and Towler, G.P. (eds). 13th International Symposium on Process Systems Engineering (PSE 2018), San Diego, California, USA, 1-5 July 2018, pp.2107-2112.|
|Series/Report no.: ||Computer Aided Chemical Engineering;44|
|Abstract: ||In this work, a plant-wide model-based shortcut approach for decision-making and operational analysis of integrated end-to-end continuous pharmaceutical processes is developed and tested. The proposed hierarchical approach is implemented through a computer-aided framework. Using concepts of Layer of Protection Analysis (LOPA) combined with Net Present Value (NPV) are embedded in the framework from a model-based point of view to comprehensively assess the overall benefits of a specific operational point. This in turn can be used to make an informed decision between competing operation alternatives. The application of the framework is demonstrated through a validated dynamic process model of an integrated end-to-end continuous pharmaceutical pilot plant. In this application, the implications of changing process operations from single pass operation to raw material recycling have been investigated.|
|Description: ||This conference paper is closed access.|
|Sponsor: ||The project received financial support from Innovation Fund Denmark through the BIOPRO2 strategic research center (Grant number 4105-00020B).|
|Version: ||Accepted for publication|
|Publisher Link: ||https://doi.org/10.1016/B978-0-444-64241-7.50346-3|
|Appears in Collections:||Closed Access (Chemical Engineering)|
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