Derivatives of Diels-Alder adducts of thebaine and of
14-hydroxy codeinone provide some of the most potent analgesics
in the morphine-thebaine group of alkaloids. As an extension to
the range of available compounds, the preparation of further
modified thebaines and 14-hydroxy codeinone was investigated. [Continues.]
A Masters Thesis. Submitted in partial fulfilment of the requirements for the award of Master of Philosophy of Loughborough University.