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Title: Psychological distress and infectious disease mortality in the general population
Authors: Hamer, Mark
Kivimaki, Mika
Stamatakis, Emmanuel
Batty, G. David
Keywords: Depression
Bacterial infections
Virus diseases
Issue Date: 2018
Publisher: © Elsevier
Citation: HAMER, M. ... et al, 2018. Psychological distress and infectious disease mortality in the general population. Brain, Behavior, and Immunity, 76, pp.280-283.
Abstract: There is a paucity of studies examining the relation between high psychological distress and infectious disease in the general population. We examined this association in a large multi-cohort study drawn from the general population. The analytic sample comprised 104,923 men and women (age, 47.3 ± 17.4 year; 45.7% men) in which psychological distress symptoms was assessed using the 12-item version of the General Health Questionnaire. There were 1535 deaths attributed to infectious diseases during 971,220 person-years of follow up (mean 9.3; range 0.1–17.1 years). A dose-response association between GHQ-12 score and all infectious disease mortality was observed after adjusting for age, sex, survey year, occupational social class, longstanding illness, smoking, alcohol, and physical activity (per SD increase, hazard ratio = 1.24; 95% CI, 1.20–1.28). A similar pattern was apparent for viral infections (1.23; 1.14, 1.33) and pneumonia (1.20; 1.13, 1.28), but weaker for bacterial infections (1.09; 1.00, 1.19). In conclusion, psychological distress is associated with higher risk of infectious disease.
Description: This paper is closed access until 20 December 2019.
Version: Accepted for publication
DOI: 10.1016/j.bbi.2018.12.011
URI: https://dspace.lboro.ac.uk/2134/36513
Publisher Link: https://doi.org/10.1016/j.bbi.2018.12.011
ISSN: 0889-1591
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

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