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Title: Physical activity and sedentary time: association with metabolic health and liver fat
Authors: Bowden Davies, Kelly A.
Sprung, Victoria S.
Norman, Juliette A.
Thompson, Andrew
Mitchell, Katie L.
Harrold, Jo A.
Finlayson, Graham
Gibbons, Catherine
Wilding, John P.
Kemp, Graham J.
Hamer, Mark
Cuthbertson, Daniel J.
Keywords: Body composition
Magnetic resonance spectroscopy
Metabolic syndrome
Insulin regulation
Cardio-respiratory fitness
Metabolic equivalents
Issue Date: 2019
Publisher: Lippincott, Williams & Wilkins © The Authors
Citation: BOWDEN DAVIES, K.A. ... et al., 2019. Physical activity and sedentary time: association with metabolic health and liver fat. Medicine and Science in Sports and Exercise, 51(6), pp. 1169–1177.
Abstract: Introduction/Purpose To investigate whether a) lower levels of daily physical activity (PA) and greater sedentary time accounted for contrasting metabolic phenotypes (higher liver fat/presence of metabolic syndrome [MetS+] vs lower liver fat/absence of metabolic syndrome [MetS-]) in individuals of similar BMI and b) the association of sedentary time on metabolic health and liver fat. Methods Ninety-eight habitually active participants (53 female, 45 male; age 39±13 years; BMI 26.9±5.1 kg/m2), underwent assessments of PA (SenseWear armband; wear time ~98%), cardio-respiratory fitness (V̇O2 peak), body composition (MRI and MRS) and multi-organ insulin sensitivity (OGTT). We undertook a) cross-sectional analysis comparing four groups: non-obese or obese, with and without metabolic syndrome (MetS+ vs MetS-) and b) univariate and multivariate regression for sedentary time and other levels of PA in relation to liver fat. Results Light, moderate and vigorous PA did not account for differences in metabolic health between individuals, whether non-obese or obese, although MetS+ individuals were more sedentary, with a higher number, and prolonged bouts (~1-2 hours). Overall, sedentary time, average daily METS and V̇O2 peak were each independently associated with liver fat percentage. Each additional hour of daily sedentary time was associated with a 1.15% (95% CI, 1.14–1.50%) higher liver fat content. Conclusions Greater sedentary time, independent of other levels of PA, is associated with being metabolically unhealthy; even in habitually active people, lesser sedentary time, and higher cardio-respiratory fitness and average daily METS is associated with lower liver fat.
Description: This is an Open Access Article. It is published by Lippincott, Williams & Wilkins under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: Original funding support by Diabetes UK (grant number 13/0004719) with additional support from the MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) and internal funding from Institute of Ageing and Chronic Disease, University of Liverpool.
Version: Published version
DOI: 10.1249/MSS.0000000000001901
URI: https://dspace.lboro.ac.uk/2134/36547
Publisher Link: https://doi.org/10.1249/MSS.0000000000001901
ISSN: 0195-9131
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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