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|Title: ||Physical activity and sedentary time: association with metabolic health and liver fat|
|Authors: ||Bowden Davies, Kelly A.|
Sprung, Victoria S.
Norman, Juliette A.
Mitchell, Katie L.
Harrold, Jo A.
Wilding, John P.
Kemp, Graham J.
Cuthbertson, Daniel J.
|Keywords: ||Body composition|
Magnetic resonance spectroscopy
|Issue Date: ||2019|
|Publisher: ||Lippincott, Williams & Wilkins © The Authors|
|Citation: ||BOWDEN DAVIES, K.A. ... et al., 2019. Physical activity and sedentary time: association with metabolic health and liver fat. Medicine and Science in Sports and Exercise, doi:10.1249/MSS.0000000000001901.|
|Abstract: ||Introduction/Purpose To investigate whether a) lower levels of daily physical activity (PA) and greater sedentary time accounted for contrasting metabolic phenotypes (higher liver fat/presence of metabolic syndrome [MetS+] vs lower liver fat/absence of metabolic syndrome [MetS-]) in individuals of similar BMI and b) the association of sedentary time on metabolic health and liver fat.
Methods Ninety-eight habitually active participants (53 female, 45 male; age 39±13 years; BMI 26.9±5.1 kg/m2), underwent assessments of PA (SenseWear armband; wear time ~98%), cardio-respiratory fitness (V̇O2 peak), body composition (MRI and MRS) and multi-organ insulin sensitivity (OGTT). We undertook a) cross-sectional analysis comparing four groups: non-obese or obese, with and without metabolic syndrome (MetS+ vs MetS-) and b) univariate and multivariate regression for sedentary time and other levels of PA in relation to liver fat.
Results Light, moderate and vigorous PA did not account for differences in metabolic health between individuals, whether non-obese or obese, although MetS+ individuals were more sedentary, with a higher number, and prolonged bouts (~1-2 hours). Overall, sedentary time, average daily METS and V̇O2 peak were each independently associated with liver fat percentage. Each additional hour of daily sedentary time was associated with a 1.15% (95% CI, 1.14–1.50%) higher liver fat content.
Conclusions Greater sedentary time, independent of other levels of PA, is associated with being metabolically unhealthy; even in habitually active people, lesser sedentary time, and higher cardio-respiratory fitness and average daily METS is associated with lower liver fat.|
|Description: ||This paper is in closed access until 1 January 2020.|
|Sponsor: ||Original funding support by Diabetes UK (grant number 13/0004719) with additional support from the MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) and internal funding from Institute of Ageing and Chronic Disease, University of Liverpool.|
|Version: ||Accepted for publication|
|Publisher Link: ||https://doi.org/10.1249/MSS.0000000000001901|
|Appears in Collections:||Closed Access (Sport, Exercise and Health Sciences)|
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