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Title: Theoretical modeling of polymer translocation: From the electrohydrodynamics of short polymers to the fluctuating long polymers
Authors: Buyukdagli, Sahin
Sarabadani, Jalal
Ala-Nissila, Tapio
Keywords: Polymer translocation
Dielectric membranes
Electrostatic interactions
Charge screening
Issue Date: 2019
Publisher: © The Authors. Published by MDPI AG
Citation: BUYUKDAGLI, S., SARABADANI, J. and ALA-NISSILA, T., 2019. Theoretical modeling of polymer translocation: From the electrohydrodynamics of short polymers to the fluctuating long polymers. Polymers, 11(1): 118 .
Abstract: The theoretical formulation of driven polymer translocation through nanopores is complicated by the combination of the pore electrohydrodynamics and the nonequilibrium polymer dynamics originating from the conformational polymer fluctuations. In this review, we discuss the modeling of polymer translocation in the distinct regimes of short and long polymers where these two effects decouple. For the case of short polymers where polymer fluctuations are negligible, we present a stiff polymer model including the details of the electrohydrodynamic forces on the translocating molecule. We first show that the electrohydrodynamic theory can accurately characterize the hydrostatic pressure dependence of the polymer translocation velocity and time in pressure-voltage-driven polymer trapping experiments. Then, we discuss the electrostatic correlation mechanisms responsible for the experimentally observed DNA mobility inversion by added multivalent cations in solid-state pores, and the rapid growth of polymer capture rates by added monovalent salt in α -Hemolysin pores. In the opposite regime of long polymers where polymer fluctuations prevail, we review the iso-flux tension propagation (IFTP) theory, which can characterize the translocation dynamics at the level of single segments. The IFTP theory is valid for a variety of polymer translocation and pulling scenarios. We discuss the predictions of the theory for fully flexible and rodlike pore-driven and end-pulled translocation scenarios, where exact analytic results can be derived for the scaling of the translocation time with chain length and driving force.
Description: This is an Open Access Article. It is published by MDPI under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: This research was funded by the Academy of Finland QTF Centre of Excellence program (project 312298).
Version: Published
DOI: 10.3390/polym11010118
URI: https://dspace.lboro.ac.uk/2134/36704
Publisher Link: https://doi.org/10.3390/polym11010118
Appears in Collections:Published Articles (Maths)

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