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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/36711

Title: Additively manufactured flow-resistive pulse sensors
Authors: Hampson, Sarah
Pollard, Marcus
Hauer, Peter
Salway, Hayden
Christie, Steven D.R.
Platt, Mark
Issue Date: 2019
Publisher: © American Chemical Society (ACS)
Citation: HAMPSON, S. ... et al, 2019. Additively manufactured flow-resistive pulse sensors. Analytical Chemistry, 91 (4), pp.2947-2954.
Abstract: Resistive pulse sensors (RPSs) provide detailed characterization of materials from the nanoparticle up to large biological cells on a particle-to-particle basis. During the RPS experiment, particles pass through a channel or pore that conducts ions, and the change in the ionic current versus time is monitored. The change in current during each translocation, also known as a “pulse”, is dependent on the ratio of the particle and channel dimensions. Here we present a facile and rapid method for producing flow-RPSs that do not require lithographic processes. The additively manufactured sensor has channel dimensions that can be easily controlled. In addition, the fabrication process allows the sensor to be quickly assembled, disassembled, cleaned, and reused. Furthermore, the RPS can be created with a direct interface for fluidic pumps or imaging window for complementary optical microscopy. We present experiments and simulations of the RPS, showing how the pulse shapes are dependent on the channel morphology and how the device can count and size particles across a range of flow rates and ionic strengths. The use of pressure-driven fluid flow through the device allowed a rapid characterization of particles down to concentrations as low as 1 × 10–3 particles per mL, which equated to one event per second.
Description: This paper is closed access until 17 January 2020.
Sponsor: We thank Loughborough University for the funding of this research. We are grateful to the EPSRC Centre for Doctoral Training in Embedded Intelligence under grant reference EP/L014998/1 for financial support.
Version: Accepted for publication
DOI: 10.1021/acs.analchem.8b05140
URI: https://dspace.lboro.ac.uk/2134/36711
Publisher Link: https://doi.org/10.1021/acs.analchem.8b05140
ISSN: 0003-2700
Appears in Collections:Closed Access (Chemistry)

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