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Title: Versatile reconfigurable glass capillary microfluidic devices with Lego® inspired blocks for drop generation and micromixing
Authors: Bandulasena, Monalie V.
Vladisavljevic, Goran T.
Benyahia, Brahim
Keywords: Glass capillary microfluidics
CNC milling
Micromixing
Metal nanoparticles
Liposomes
Microfluidic antisolvent crystallisation
Issue Date: 2019
Publisher: Elsevier © The Authors
Citation: BANDULASENA, M.V., VLADISAVLJEVIC, G.T. and BENYAHIA, B., 2019. Versatile reconfigurable glass capillary microfluidic devices with Lego® inspired blocks for drop generation and micromixing. Journal of Colloid and Interface Science, 542, pp.23-32.
Abstract: Novel cost effective, versatile, reconfigurable, reusable and easy to assemble glass capillary microfluidic devices were developed and used to generate micro/nano-materials with controlled size and morphology. The devices are composed of coaxial assemblies of glass capillaries held between two interchangeable plastic blocks fabricated from chemically inert polyoxymethylene copolymer using computer numerical control (CNC) machining. Three different blocks were combined and locked together using Lego® inspired stud-and-hole coupling system to achieve different flow configurations. The device allows a truly axisymmetric round capillary inside a round capillary geometry and self-alignment of capillaries. The synthesis of polyvinylpyrrolidone capped gold nanoparticles and liposomes of controlled size was demonstrated in the co-flow device by mixing the contents of two parallel laminar streams. The flow focusing device was used to generate piroxicam monohydrate crystals of controlled size (10–29 μm) by antisolvent crystallisation. Silver nanoparticles with tailored size (40–90 nm) were prepared in the three-phase device by merging silver nitrate and tannic acid/citrate streams inside droplets. The same device was used to prepare fluorescently labelled double emulsion droplets with controlled number of inner droplets. The droplet morphology was modified and tuned during operation by adjusting the distance between the inner capillaries. Water-in-oil emulsions consisted of Eudragit S100 solution at pH > 7 dispersed in Miglyol® 840 were prepared and gellified in situ over 6 h without fouling. The setup time of the novel devices was reduced from ∼30 min in manually made capillary devices to just several minutes.
Description: This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Sponsor: The authors acknowledge the financial support for this work from the Enterprise Projects Group (EPG) of Loughborough University, grant 18/14606. The experimental set-up was provided from the UK Engineering and Physical Sciences Research Council (EPSRC) grant EP/HO29923/1.
Version: Published
DOI: 10.1016/j.jcis.2019.01.119
URI: https://dspace.lboro.ac.uk/2134/36773
Publisher Link: https://doi.org/10.1016/j.jcis.2019.01.119
ISSN: 0021-9797
Appears in Collections:Published Articles (Chemical Engineering)

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