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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/36851

Title: Mask-free laser lithography for rapid and low-cost microfluidic device fabrication
Authors: Trantidou, Tatiana
Friddin, Mark S.
Gan, Kin B.
Han, Luyao
Bolognesi, Guido
Brooks, Nicholas J.
Ces, Oscar
Issue Date: 2018
Publisher: © American Chemical Society
Citation: TRANTIDOU, T. ... et al., 2018. Mask-free laser lithography for rapid and low-cost microfluidic device fabrication. Analytical Chemistry, 90(23), pp. 13915 - 13921.
Abstract: Copyright © 2018 American Chemical Society. Microfluidics has become recognized as a powerful platform technology associated with a constantly increasing array of applications across the life sciences. This surge of interest over recent years has led to an increased demand for microfluidic chips, resulting in more time being spent in the cleanroom fabricating devices using soft lithography - a slow and expensive process that requires extensive materials, training and significant engineering resources. This bottleneck limits platform complexity as a byproduct of lengthy delays between device iterations and affects the time spent developing the final application. To address this problem, we report a new, rapid, and economical approach to microfluidic device fabrication using dry resist films to laminate laser cut sheets of acrylic. We term our method laser lithography and show that our technique can be used to engineer 200 μm width channels for assembling droplet generators capable of generating monodisperse water droplets in oil and micromixers designed to sustain chemical reactions. Our devices offer high transparency, negligible device to device variation, and low X-ray background scattering, demonstrating their suitability for real-time X-ray-based characterization applications. Our approach also requires minimal materials and apparatus, is cleanroom free, and at a cost of around $1.00 per chip could significantly democratize device fabrication, thereby increasing the interdisciplinary accessibility of microfluidics.
Description: This paper is in closed access until 5th Nov 2019.
Sponsor: This work was supported by the EPSRC via grants EP/J017566/1 and EP/K038648/1.
Version: Accepted for publication
DOI: 10.1021/acs.analchem.8b03169
URI: https://dspace.lboro.ac.uk/2134/36851
Publisher Link: https://doi.org/10.1021/acs.analchem.8b03169
ISSN: 0003-2700
Appears in Collections:Closed Access (Chemical Engineering)

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