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Title: The effect of exercise intensity on circulating hepatokine concentrations in healthy men
Authors: Willis, Scott A.
Sargeant, Jack A.
Thackray, Alice E.
Yates, Thomas E.
Stensel, David J.
Aithal, Guruprasad P.
King, James A.
Keywords: Exercise
Physical activity
Insulin resistance
Issue Date: 2019
Publisher: NRC Research Press © The authors
Citation: WILLIS, S.A. ... et al, 2019. The effect of exercise intensity on circulating hepatokine concentrations in healthy men. Applied Physiology, Nutrition, and Metabolism, [in press].
Abstract: Fibroblast growth factor 21 (FGF21), follistatin and leukocyte cell-derived chemotaxin 2 (LECT2) are novel hepatokines which are modulated by metabolic stresses. This study investigated whether exercise intensity modulates the hepatokine response to acute exercise. Ten young, healthy men undertook three 8-h experimental trials: moderate-intensity exercise (MOD; 55% V̇O2 peak), high-intensity exercise (HIGH; 75% V̇O2 peak) and control (CON; rest), in a randomised, counterbalanced order. Exercise trials commenced with a treadmill run of varied duration to match gross exercise energy expenditure between trials (MOD vs HIGH; 2475 ± 70 vs 2488 ± 58 kJ). Circulating FGF21, follistatin, LECT2, glucagon, insulin, glucose and non-esterified fatty acids (NEFA) were measured before exercise and at 0, 1, 2, 4 and 7 h post-exercise. Plasma FGF21 concentrations were increased up to 4 h post-exercise compared to CON (P ≤ 0.022) with greater increases observed at 1, 2 and 4 h post-exercise during HIGH vs MOD (P ≤ 0.025). Irrespective of intensity (P ≥ 0.606), plasma follistatin concentrations were elevated at 4 and 7 h post-exercise (P ≤ 0.053). Plasma LECT2 concentrations were increased immediately post-exercise (P ≤ 0.046) but were not significant after correcting for plasma volume shifts. Plasma glucagon (1 h; P = 0.032) and NEFA (4 and 7 h; P ≤ 0.029) responses to exercise were accentuated in HIGH vs MOD. These findings demonstrate that acute exercise augments circulating FGF21 and follistatin. Exercise-induced changes in FGF21 are intensity-dependent and may support the greater metabolic benefit of high-intensity exercise.
Description: This paper is closed access until it is published.
Sponsor: The research was funded by the National Institute for Health Research (NIHR) Leicester and Nottingham Biomedical Research Centres. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.
Version: Accepted for publication
URI: https://dspace.lboro.ac.uk/2134/36853
Publisher Link: http://www.nrcresearchpress.com/toc/apnm/current
ISSN: 1066-7814
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

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