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Title: Chitosan & conductive PANI/Chitosan composite nanofibers - Evaluation of antibacterial properties
Authors: Moutsatsou, Panagiota
Coopman, Karen
Georgiadou, Stella
Keywords: Polyaniline
Chitosan
Nanofibers
Wound dressing
Electrospinning parameters
Antimicrobial properties
Voltage
Humidity
Issue Date: 2019
Publisher: © Bentham Science Publishers Ltd.
Citation: MOUTSATSOU, P., COOPMAN, K. and GEORGIADOU, S., 2019. Chitosan & conductive PANI/Chitosan composite nanofibers - Evaluation of antibacterial properties. Current Nanomaterials, 4(1) , pp. 6 - 20.
Abstract: Within the healthcare industry, including the treatment of chronic wounds, the challenge of antimicrobial resistance continues to grow. As such, there is a need to develop new treatments that can reduce the bioburden in wounds. The present study is focused on the development of conductive polyaniline (PANI) / chitosan (CH) nanofibrous electrospun membranes and evaluates their antibacterial properties. The blended fibre membranes combine the materials’ respective properties such as electrical conductivity, biocompatibility and antibacterial activity. To this end, experimental design was used to determine the electrospinning windows of both pure chitosan and PANI/CH blends of different ratios (1:3, 3:5, 1:1). The effect of key environmental and process parameters (relative humidity and applied voltage) was determined, as well as the effect of the PANI/CH ratio in the blend, and the molecular interactions between PANI and Chitosan that led to jet stability. The nanofibrous mats were evaluated regarding their morphology and antibacterial effect against gram positive and gram negative bacterial strains, namely B. subtilis and E. coli. High PANI content mats show increased bactericidal activity against both bacterial strains. This study suggests that electrospun PANI/CH membranes are promising candidates for healthcare applications such as wound dressings.
Description: This paper is closed access until 14-11- 2019.
Version: Accepted for publication
DOI: 10.2174/1573413714666181114110651
URI: https://dspace.lboro.ac.uk/2134/36926
Publisher Link: https://doi.org/10.2174/1573413714666181114110651
ISSN: 2405-4615
Appears in Collections:Closed Access (Chemical Engineering)

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