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Title: Mechanical and chemical characterisation of bioresorbable polymeric stent over two-year in vitro degradation
Authors: Naseem, Raasti
Zhao, Liguo
Silberschmidt, Vadim V.
Liu, Yang
Scaife, O.W.
Willcock, Helen
Eswaran, S.K.
Hossainy, S.
Keywords: Polymeric stent
Material properties
Berkovich nanoindentation
Atomic force microscopy
in vitro degradation
Issue Date: 2019
Publisher: SAGE Publications © The Authors
Citation: NASEEM, R. ... et al, 2019. Mechanical and chemical characterisation of bioresorbable polymeric stent over two-year in vitro degradation. Journal of Biomaterials Applications, 34 (1), pp.61-73.
Abstract: Polymeric stent is a temporary cardiovascular scaffold, made of biodegradable poly (l-lactic) acid, to treat coronary artery stenosis, with expected resorption by the human body over two to three years. In this paper, the mechanical properties of a polymeric stent over two-year in vitro degradation were studied and characterised using atomic force microscopy and nanoindentation techniques, complemented with analyses of weight loss, gel permeation chromatography and differential scanning calorimetry. Atomic force microscopy assessed stent degradation at the surface, whilst nanoindentation was able to investigate the property at a greater depth into the material. No significant changes to the Young’s modulus were observed with the atomic force microscopy due to bulk degradation nature of the polymer. Chemical analyses demonstrated a reduction of molecular weight and an increase of crystallinity, indicating degradation of the stents. Berkovich nanoindentation showed a trend of reduction in modulus over in vitro degradation, which was, however, not continuous due to the variations of measurements associated with the pyramidal indenter tip and the semi-crystalline structure of the polymer.
Description: This paper was accepted for publication in the journal Journal of Biomaterials Applications and the definitive published version is available at https://doi.org/10.1177/0885328219839591.
Sponsor: This work is funded by the British Heart Foundation PhD research project (Grant number: FS/15/21/31424; Title: Towards controlling the mechanical performance of polymeric bioresorbable vascular stent during biodegradation).
Version: Accepted for publication
DOI: 10.1177/0885328219839591
URI: https://dspace.lboro.ac.uk/2134/37159
Publisher Link: https://doi.org/10.1177/0885328219839591
ISSN: 0885-3282
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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