Korossis_Akram_paper2.pdf (7.7 MB)
Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress–strain distribution on the aortic valve
journal contribution
posted on 2019-03-15, 10:46 authored by Akram Joda, Zhongmin Jin, Axel Haverich, Jon Summers, Sotiris KorossisSotiris KorossisThis study developed a realistic 3D FSI computational model of the aortic valve using the fixed-grid
method, which was eventually employed to investigate the effect of the leaflet thickness inhomogeneity
and leaflet mechanical nonlinearity and anisotropy on the simulation results. The leaflet anisotropy and
thickness inhomogeneity were found to significantly affect the valve stress–strain distribution. However,
their effect on valve dynamics and fluid flow through the valve were minor. Comparison of the simulation results against in-vivo and in-vitro data indicated good agreement between the computational
models and experimental data. The study highlighted the importance of simulating multi-physics phenomena (such as fluid flow and structural deformation), regional leaflet thickness inhomogeneity and
anisotropic nonlinear mechanical properties, to accurately predict the stress–strain distribution on the
natural aortic valve.
Funding
The work was supported by a Marie Curie EST Fellowship (MEST/CT/2005/020327), the Leeds Center of Excellence in Medical Engineering, funded by the Wellcome Trust and the Engineering and Physical Sciences Research Council (WT088908/z/09/ z), and by an Engineering and Physical Sciences Research Council Advanced Research Fellowship (EP/D073618/1).
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
Journal of BiomechanicsVolume
49Issue
12Pages
2502 - 2512Citation
JODA, A. ... et al., 2016. Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress–strain distribution on the aortic valve. Journal of Biomechanics, 49(12), pp. 2502 - 2512.Publisher
Crown © Published by Elsevier BVVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2016-03-05Notes
This paper was accepted for publication in the journal Journal of Biomechanics and the definitive published version is available at https://doi.org/10.1016/j.jbiomech.2016.02.041ISSN
0021-9290Publisher version
Language
- en