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Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies
journal contribution
posted on 2019-03-15, 11:05 authored by Nicholas Roberts, Lucrezia Morticelli, Zhongmin Jin, Eileen Ingham, Sotiris KorossisSotiris KorossisThe aim of this study was to investigate the regional and directional differences in the biomechanics and
histoarchitecture of the porcine mitral valve (MV) apparatus, with a view to tailoring tissue-engineered
constructs for MV repair. The anterior leaflet displayed the largest directional anisotropy with significantly higher strength in the circumferential direction compared to the posterior leaflet. The histological results indicated that this was due to the circumferential alignment of the collagen fibers. The
posterior leaflet demonstrated no significant directional anisotropy in the mechanical properties, and
there was no significant directionality of the collagen fibers in the main body of the leaflet. The thinner
commissural chordae were found to be significantly stiffer and less extensible than the strut chordae.
Histological staining demonstrated a tighter knit of the collagen fibers in the commissural chordae than
the strut chordae. By elucidating the inhomogeneity of the histoarchitecture and biomechanics of the MV
apparatus, the results from this study will aid the regional differentiation of MV repair strategies, with
tailored mitral-component-specific biomaterials or tissue-engineered constructs.
Funding
This research was supported by the Engineering and Physical Sciences Research Council (EPSRC; EP/D073618/1) Advanced Research Fellowship and by the Leeds Center of Excellence in Medical Engineering funded by the Wellcome Trust and EPSRC (WT088908/z/09/z).
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
Journal of BiomechanicsVolume
49Issue
12Pages
2491 - 2501Citation
ROBERTS, N. ... et al., 2016. Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies. Journal of Biomechanics, 49(12), pp. 2491 - 2501.Publisher
Crown © Published by Elsevier BVVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2015-12-30Notes
This paper is in closed access.ISSN
0021-9290Publisher version
Language
- en