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|Title: ||True interindividual variability exists in postprandial appetite responses in healthy men but is not moderated by the FTO genotype|
|Authors: ||Goltz, Fernanda R.|
Thackray, Alice E.
King, James A.
Dorling, James L.
Mastana, Sarabjit S.
Stensel, David J.
Replicated crossover design
|Issue Date: ||2019|
|Publisher: ||Oxford University Press (OUP)|
|Citation: ||GOLTZ, F.R. ... et al., 2019. True interindividual variability exists in postprandial appetite responses in healthy men but is not moderated by the FTO genotype. Journal of Nutrition, In Press.|
|Abstract: ||Background: After meal ingestion, a series of coordinated hormone responses occur
concomitantly with changes in perceived appetite. It is not known whether interindividual
variability in appetite exists in response to a meal. Objectives: This study aimed to 1) assess
the reproducibility of appetite responses to a meal; 2) quantify individual differences in
responses; and 3) explore any moderating influence of the fat mass and obesity associated
(FTO) gene. Methods: Using a replicated crossover design, 18 healthy men (mean ± SD 28.5
± 9.8 years, 27.0 ± 5.0 kg·m-2
) recruited according to FTO genotype (9 AA, 9 TT) completed
two identical control and two identical standardized meal conditions (5025 kJ) in randomized
sequences. Perceived appetite and plasma acylated ghrelin, total peptide YY (PYY), insulin
and glucose concentrations were measured before and after interventions as primary
outcomes. Interindividual differences were explored using Pearson’s product-moment
correlations between the first and second replicate of the control-adjusted meal response.
Within-participant covariate-adjusted linear mixed models were used to quantify participant by-condition and genotype-by-condition interactions. Results: The meal suppressed acylated
ghrelin and appetite perceptions (standardized effect sizes (ES): 0.18-4.26) and elevated total
PYY, insulin and glucose (ES: 1.96-21.60). For all variables, SD of change scores was
greater in the meal versus control conditions. Moderate-to-large positive correlations were
observed between the two replicates of control-adjusted meal responses for all variables
(r=0.44-0.86, P≤0.070). Participant-by-condition interactions were present for all variables
(P≤0.056). FTO genotype-by-condition interactions were not significant (P≥0.19) and
treatment effect differences between genotype groups were small (ES≤0.27) for all appetite
parameters. Conclusions: Reproducibility of postprandial appetite responses is generally
good. True interindividual variability is present beyond any random within-subject variation
in healthy men but is not moderated by the FTO genotype. These findings highlight the
importance of exploring individual differences in appetite for the prevention and/or treatment
of obesity. Clinical trial registry number: NCT03771690 (ClinicalTrials.gov).|
|Description: ||This paper is in closed access until 12 months after publication.|
|Sponsor: ||This research was funded by the NIHR Leicester Biomedical Research
|Version: ||Accepted for publication|
|Publisher Link: ||https://academic.oup.com/jn|
|Appears in Collections:||Closed Access (Sport, Exercise and Health Sciences)|
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