Thesis-2019-CostaMarques.pdf (6.62 MB)
Microglia: cell therapy for Alzheimer's disease
thesis
posted on 2019-04-24, 11:33 authored by Luis Costa-MarquesAlzheimer’s disease (AD) is the most common type of dementia (>70% of the cases). Although it was discovered more than one century ago, the existing treatments for AD only produce a modest amelioration of the symptoms and there is still no available cure. AD not only causes severe distress to the patients and caregivers, but it is also associated with a large economic burden to society, since after the age of 65, the risk of developing AD doubles every five years, and by the age 85 the prevalence increases to 50%. This large and global impact is inherently associated with current major challenges in AD, which include the lack of effective treatments, preventive strategies and reliable biomarkers for early diagnosis. [Continues.]
Funding
EPSRC
MRC
History
School
- Mechanical, Electrical and Manufacturing Engineering
Publisher
Loughborough UniversityRights holder
© Luís MarquesPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2019Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.Language
- en
Supervisor(s)
Alexandra StolzingQualification name
- PhD
Qualification level
- Doctoral