Jumping in phase diagram - CGD -revised final.pdf (869.23 kB)
Jumping into metastable 1:1 urea-succinic acid cocrystal zone by freeze-drying
journal contribution
posted on 2019-04-25, 14:59 authored by Qiushuo Yu, Jiaojiao Pu, Min Qi, Huaiyu YangHuaiyu YangAqueous solutions with molar ratios between urea and succinic acid from 0.3:1 to 3:1 were evaporated at room temperature, and products were pure or mixtures of stable 2:1 urea-succinic acid cocrystals, urea or succinic acid. By freeze-drying, metastable 1:1 urea-succinic acid cocrystal formed. The different mixtures of the 1:1 cocrystals reveal several "hidden" metastable zones in a ternary phase diagram of the 2:1 cocrystal. The formation of the 1:1 cocrystal indicated that the solution composition points in the phase diagram "jump" over the stable zone into the metastable zones.
Funding
Natural Science Foundation of Shaanxi Province (2013JQ2020) and National Science Foundation (NSFC. 21106110, 21536009).
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
Crystal Growth and DesignCitation
YU, Q. ... et al, 2019. Jumping into metastable 1:1 urea-succinic acid cocrystal zone by freeze-drying. Crystal Growth and Design, 19 (3), pp.1505–1508.Publisher
© American Chemical SocietyVersion
- AM (Accepted Manuscript)
Publisher statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.8b01778.Publication date
2019-01-29ISSN
1528-7483eISSN
1528-7505Publisher version
Language
- en
