Mansukoski_et_al-2019-American_Journal_of_Human_Biology.pdf (1.97 MB)
Life course associations of height, weight, fatness, grip strength, and all-cause mortality for high socioeconomic status Guatemalans
journal contribution
posted on 2019-05-02, 09:57 authored by Liina Mansukoski, Will JohnsonWill Johnson, Katherine Brooke-WavellKatherine Brooke-Wavell, J. Andres Galvez-Sobral, L.R. Furlan, Tim J. Cole, Barry BoginObjectives: The objective of this study was to investigate the association between physical growth in pre-adult life with five outcomes at age 64-76: weight, body mass index, estimated body fat percentage, hand grip strength and mortality.
Methods: Super-Imposition by Translation and Rotation (SITAR) growth curves of 40,484 Guatemalan individuals aged 3-19 years were modelled for the parameters of size, timing and intensity (peak growth velocity, e.g. cm/year) of height, weight, body mass index, and grip strength. Associations between the SITAR parameters and old age outcomes were tested using linear and binary logistic regression for a follow-up sample of high socioeconomic status (SES) Guatemalans, of whom 50 were aged 64-76 years old at re-measurement and 45 died prior to the year 2017.
Results: SITAR models explained 69-98% of the variance in each outcome, with height the most precise. Individuals in the follow-up sample who had a higher BMI before age 20 years had higher estimated body fat (B=1.4 CI -0.02-2.8) and BMI (B=1.2, CI 0.2-2.2) at the ages 64-76 years. Those who grew slower in height but faster in weight and BMI before age 20 years, had higher BMI and body fat later in life.
Conclusions: These findings highlight the importance of a life course perspective on health and mortality risk. Childhood exposures leading to variation in pre-adult growth may be key to better understanding health and mortality risks in old age.
Funding
LM is supported by a PhD Grant from the Finnish Osk. Huttunen Foundation. Digitisation of the UVG Study data records was supported by both the UVG and the Healthy Birth, Growth and Development knowledge integration (HBGDki) programme of the Bill & Melinda Gates Foundation (contract OPP1125811) awarded to BB. WJ is supported by a UK Medical Research Council (MRC) New Investigator Research Grant (MR/P023347/1) and acknowledges support from the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre, which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University, and the University of Leicester. TJC is funded by MRC research grant MR/R010692/1.
History
School
- Sport, Exercise and Health Sciences
Published in
American Journal of Human BiologyVolume
31Issue
4Pages
e23253Citation
MANSUKOSKI, L.M. ... et al., 2019. Life course associations of height, weight, fatness, grip strength, and all-cause mortality for high socioeconomic status Guatemalans. American Journal of Human Biology, 31 (4), e23253.Publisher
Wiley © The AuthorsVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/Acceptance date
2019-05-01Publication date
2019-05-15Copyright date
2019Notes
This is an Open Access article. It is published by Wiley under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/ISSN
1042-0533Publisher version
Language
- en