Manuscript file_revised version_15.07.2019.pdf (1.85 MB)
Poly(4-vinylaniline)/polyaniline bilayer functionalized bacterial cellulose for flexible electrochemical biosensors
journal contribution
posted on 2019-07-19, 12:57 authored by Ana M. Rodrigues Rebelo, Changqing Liu, Karl-Herbert Schafer, Monika Saumer, Guang Yang, Yang LiuYang LiuBacterial cellulose (BC) nanofibril network is modified with an electrically conductive
polyvinylaniline/polyaniline (PVAN/PANI) bilayer for construction of potential
electrochemical biosensors. This is accomplished through surface-initiated atom transfer
radical polymerization of 4-vinylaniline, followed by in situ chemical oxidative
polymerization of aniline. A uniform coverage of BC nanofiber with 1D supramolecular
PANI nanostructures is confirmed by FTIR, XRD and CHN elemental analysis. Cyclic
voltammograms evince the switching in the electrochemical behavior of BC/PVAN/PANI nanocomposites from the redox peaks at 0.74 V, in the positive scan
and at -0.70 V, in the reverse scan, (at 100 mV.s-1
scan rate). From these redox peaks,
PANI is the emeraldine form with the maximal electrical performance recorded,
showing charge-transfer resistance as low as 21 Ω and capacitance as high as 39 μF.
The voltage-sensible nanocomposites can interact with neural stem cells (NSCs)
isolated from subventricular zone (SVZ) of the brain, through stimulation and
characterization of differentiated SVZ cells into specialized and mature neurons with
long neurites measuring up to 115±24 μm length after 7 days of culture without visible
signs of cytotoxic effects. The findings pave the path to the new effective nanobiosensor
technologies for nerve regenerative medicine, which demands both electroactivity and
biocompatibility.
Funding
This research was supported by a Marie Curie International Research Staff Exchange Scheme Project of the 7th European Community Framework Program (Grant No. PIRSES-GA-2010-269113), entitled “Micro-Multi-Material Manufacture to Enable Multifunctional Miniaturized Devices (M6)”.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
LangmuirVolume
35Issue
32Pages
10354-10366Citation
REBELO, A.M.R. .... et al., 2019. Poly(4-vinylaniline)/polyaniline bilayer functionalized bacterial cellulose for flexible electrochemical biosensors. Langmuir, 35 (32), pp.10354-10366.Publisher
© American Chemical Society (ACS)Version
- AM (Accepted Manuscript)
Publisher statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.langmuir.9b01425.Acceptance date
2019-07-16Publication date
2019-07-18Copyright date
2019ISSN
0743-7463eISSN
1520-5827Publisher version
Language
- en