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Title: In vitro biocompatibility of hydroxyapatite-reinforced polymeric composites manufactured by selective laser sintering
Authors: Zhang, Y.
Hao, L.
Savalani, M.M.
Harris, Russell A.
Di Silvio, L.
Tanner, K.E.
Keywords: Biocompatibility
Composite
Hydroxyapatite
In vitro
Osteoblast cells
Polyethylene
Polyamide
Selective laser sintering
Issue Date: 2009
Publisher: © John Wiley and Sons
Citation: ZHANG, Y....et al., 2009. In vitro biocompatibility of hydroxyapatite-reinforced polymeric composites manufactured by selective laser sintering. Journal of Biomedical Materials Research, Part A, 91(4), pp.1018-1027.
Abstract: The selective laser sintering (SLS) technique was used to manufacture hydroxyapatite-reinforced polyethylene and polyamide composites as potential customized maxillofacial implants. In vitro tests were carried out to assess cellular responses, in terms of cell attachment, morphology, proliferation, differentiation, and mineralized nodule formation, using primary human osteoblast cells. This study showed that the SLS composite processed was biocompatible, with no adverse effects observed on cell viability and metabolic activity, supporting a normal metabolism and growth pattern for osteoblasts. Positive von Kossa staining demonstrated the presence of bone-like mineral on the SLS materials. Higher hydroxyapatite content composites enhanced cell proliferation, increased alkaline phosphatase activity, and produced more osteocalcin. The present findings showed that SLS materials have good in vitro biocompatibility and hence demonstrated biologically the potential of SLS for medical applications.
Description: This article is Restricted Access. It was published in the journal, Journal of Biomedical Materials Research Part A [© John Wiley & Sons] and is available at: http://dx.doi.org/10.1002/jbm.a.32298
Version: Restricted access
DOI: 10.1002/jbm.a.32298
URI: https://dspace.lboro.ac.uk/2134/4639
ISSN: 1549-3296
1552-4965
Appears in Collections:Closed Access (Mechanical and Manufacturing Engineering)

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