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|Title: ||In vitro biocompatibility of hydroxyapatite-reinforced polymeric composites manufactured by selective laser sintering|
|Authors: ||Zhang, Y.|
Harris, Russell A.
Di Silvio, L.
Selective laser sintering
|Issue Date: ||2009|
|Publisher: ||© John Wiley and Sons|
|Citation: ||ZHANG, Y....et al., 2009. In vitro biocompatibility of hydroxyapatite-reinforced polymeric composites manufactured by selective laser sintering. Journal of Biomedical Materials Research, Part A, 91(4), pp.1018-1027.|
|Abstract: ||The selective laser sintering (SLS) technique was used to manufacture hydroxyapatite-reinforced polyethylene and polyamide composites as potential customized maxillofacial implants. In vitro tests were carried out to assess cellular responses, in terms of cell attachment, morphology, proliferation, differentiation, and mineralized nodule formation, using primary human osteoblast cells. This study showed that the SLS composite processed was biocompatible, with no adverse effects observed on cell viability and metabolic activity, supporting a normal metabolism and growth pattern for osteoblasts. Positive von Kossa staining demonstrated the presence of bone-like mineral on the SLS materials. Higher hydroxyapatite content composites enhanced cell proliferation, increased alkaline phosphatase activity, and produced more osteocalcin. The present findings showed that SLS materials have good in vitro biocompatibility and hence demonstrated biologically the potential of SLS for medical applications.|
|Description: ||This article is Restricted Access. It was published in the journal, Journal of Biomedical Materials Research Part A [© John Wiley & Sons] and is available at: http://dx.doi.org/10.1002/jbm.a.32298|
|Version: ||Restricted access|
|Appears in Collections:||Closed Access (Mechanical, Electrical and Manufacturing Engineering)|
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