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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/475

Title: On the genesis of spike-wave activity in a mean-field model of human brain activity
Authors: Rodrigues, Serafim
Terry, John R.
Breakspear, Michael
Issue Date: 2005
Abstract: In this letter, the genesis of spike-wave activity - a hallmark of many generalized epileptic seizures - is investigated in a reduced mean-field model of human neural activity. Drawing upon brain modeling and dynamical systems theory, we demonstrate that the thalamic circuitry of the system is crucial for the generation of these abnormal rhythms, observing that the combination of inhibition from reticular nuclei and excitation from the external signal, interplay to generate the spike-wave oscillation. We demonstarte that this is a nonlinear phenomena and that linear stability analysis is not appropriate to explain such solutions.
Description: This is a pre-print.
URI: https://dspace.lboro.ac.uk/2134/475
Appears in Collections:Pre-prints (Maths)

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